Evaluation of HPV-16 and HPV-18 genotyping for the triage of women with high-risk HPV+ cytology-negative results. Am J Clin Pathol 2011;136:578-86.Wright TC, Stoler MH, Sharma A, Zhang G, Behrens C, Wright TL, e
Therefore, we assessed the prevalence of HPV-16/18 in the Chinese population with negative cytology and positive hrHPV results as well as the correlation of HPV-16/18 genotype test results with CIN diagnoses in patients with negative cytology results. Materials and Methods Patient Selection ...
(ASCUS) in women aged 21 and older, or in conjunction with the Pap in women aged 30 to 65. ASCCP Guidelines suggest that women aged 30 to 65 with a positive HPV and negative Pap be further evaluated for the presence of HPV Genotypes 16, 18 or other. Quest Diagnostics has modified and...
leading to the development of different platforms. Testing for HPV status in formalin-fixed, paraffin-embedded histological samples, mainly for prognostic reasons (but also as an aid in differential diagnosis), is mainly done using either DNA in situ hybridization or p16 immunohistochemistry. ...
colposcopyfor HPV-16 or -18 positive patients, and for women with other HPV genotype positivity, reflex cytology was recommend with colposcopy if the results wereASCUSor greater. Women with negative triage cytology would have a repeat cotest in 1 year. At baseline, 10.5% of women were HPV ...
Tests have been developed to identify high-risk HPV, some specifically to identify HPV 16 and 18. Young investigator challenge: Comparison of 2 different methods of manual slide screening in semiautomated gynecologic cytology. Negative gynecologic cytology cases (ie, those diagnosed as negative for ...
Results CIN3+ risks were higher for HPV16/18 than other high-risk HPV genotypes. Among women with any cytologic abnormality [atypical squamous cells of undetermined significance or worse], immediate risks were 57.8% (95%CI = 53.0–62.6%) for HPV16, 40.2% (95%CI = 32.3–49.2%) ...
The study design, population, methodology and baseline results have all been published and include high hrHPV and histology proven cervical intraepithelial neoplasia (CIN) rates in HIV-negative and HIV-positive screening populations [26]. The current analysis of the diagnostic performance of single and...
false negative results than 10% random rescreening or rescreening on the basis of clinical criteria, and this has been recommended as an internal QC method.[29–30] However, this may not be practical in a large cytology laboratory screening a high volume of cases or one with limited staff....
This comprised of repeat cytology at 6 months and a reflex HPV test in those with negative cytology, with referral to colposcopy if either was positive; all other women were returned to routine recall at 3 years (regardless of age). The results of the analysis of the test of cure protocol...