Cytokines in Cancer ImmunotherapyThomas A. WaldmannLymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutesof Health, Clinical Center, Bethesda, Maryland 20892-1374Correspondence: tawald@helix.nih.govCytokines that control the immune response were shown to have...
Therefore, heightened efforts are being made to develop new and better therapies or improve current therapies for cancer treatment. Because of their pleiotropic effects on immune cells and their role in immune activation, cytokines have emerged as potential candidates for cancer immunotherapy and hold ...
Pro-inflammatory cytokines can contribute to cancer immunotherapy, acting on every phase of the cancer immunity cycle.22,23 Thus, cytokines can improve antigen priming, increase the number of effector immune cells in the TME and enhance their cytolytic activity. However, making drugs based on cytoki...
Problems in the investigational study and clinical use of cancer immunotherapy 1990, Immunology Today Show abstract Problems in the investigational study and clinical use of cancer immunotherapy 1990, Trends in Immunology Show abstract Enhanced cytokine synthesis of leukocytes by a β-glucan preparation, ...
Alternatively, cancer cells can respond to host-derived cytokines that promote growth, attenuate apoptosis and facilitate invasion and metastasis. A more detailed understanding of cytokine–tumour-cell interactions provides new opportunities for improving cancer immunotherapy....
Targeted Cytokines for Cancer Immunotherapy Targeting of cytokines into the tumor microenvironment using antibody-cytokine fusion proteins, called immunocytokines, represents a novel approach in canc... HN Lode,RA Reisfeld - 《Immunologic Research》 被引量: 123发表: 2000年 Immunocytokines: a new appro...
Cytokines in Cancer Immunotherapy Cytokines are molecular messengers that allow the cells of the immune system to communicate with one another to generate a coordinated, robust, but self-li... S Lee,K Margolin - 《Cancers》 被引量: 660发表: 2011年 CYTOKINES IN CANCER PATHOGENESIS AND CANCER TH...
tumour development and progression. Alternatively, cancer cells can respond to host-derived cytokines that promote growth, attenuate apoptosis and facilitate invasion and metastasis. A more detailed understanding of cytokine–tumour-cell interactions provides new opportunities for improving cancer immunotherapy....
Similarly, the full effectiveness of adoptive cellular therapies for cancer immunotherapy has not yet been realized because of difficulties in sustaining T-cells in vivo following adoptive transfer. Thus, the present challenge for the field of tumor immunology is to develop clinically applicable ...
Cytokines are crucial modulators of immune responses and have emerged as key components in cancer immunotherapy, particularly concerning Natural Killer (NK) cells. Indeed, the administration of these cytokines have demonstrated significant therapeutic potential in clinical settings. For instance, interleukin-...