Advanced Therapy Medicinal Products (ATMPs) are innovative clinical treatments exploiting the pharmacological, immunological, or metabolic properties of ce... S Bellino,A La Salvia,MF Cometa,... - 《Frontiers in Pharmacology》 被引量: 0发表: 2023年 加载更多来源...
Successful culture and selection of cytokine gene-modified human dermal fibroblasts for the biologic therapy of patients with cancer. Human autologous dermal fibroblasts have been cultured, transduced with the interleukin-4 (IL-4) gene and used as a vaccine together with irradiated autolo... E,M,...
We then present an overview of therapeutics arising from cytokine re-engineering, targeting and delivery, mRNA therapeutics and cell therapy. We also highlight the application of these strategies to adjust the immunological imbalance in different immune-mediated disorders, including cancer, infection and...
B. et al. A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease. J. Autoimmun. 95, 1–14 (2018). Article CAS PubMed PubMed Central Google Scholar Levin, A. M. et al. Exploiting a natural conformational switch to ...
Adult patients clinically diagnosed with and treated for TB, 29 in Nigeria and 24 in Nepal, were analyzed.Changes in concentrations of non-specific host biomarkers, particularly IP-10, in response to the first week of anti-TB therapy were strongly associated with bacteriological confirmation of TB...
The Essential Role of Interferon-γ During Interleukin-12 Therapy for Murine Transitional Cell Carcinoma of the Bladder Recombinant interleukin (IL)-12 and adenoviral IL-12 gene therapy have been shown to be potent therapeutic interventions for murine transitional cell carci... MA O’Donnell,YI Luo...
used in CRC gene therapy and could be highly produced [57]. However, the delivery of adenovirus to the target tumor is not optimal. Therefore, Liu et al.aimed to improve the delivery by using CIK cells as second vectors. P21Ras could be a potential target for gene therapy in CRC. Liu...
Cytokines in immune pathogenesis and therapy Edited byDr. Kamal Moudgil Last update October 2015 IL 4/IL 13 family Edited byDr. Achsah Keegan Last update September 2015 ICIS Awardee Reviews Edited by Dhan V. Kalvakolanu Sarah L. Gaffen
IL-10 Regulates Liver Pathology in Acute Murine Schistosomiasis mansoni But Is Not Required for Immune Down-Modulation of Chronic Disease We have used IL-10 gene knockout mice (IL-10T) to examine the role of endogenous IL-10 in the down-modulation of hepatic granuloma formation and lymphocyte...
Extracorporeal Photochemotherapy Induces the Production of Tumor Necrosis Factor-α by Monocytes: Implications for the Treatment of Cutaneous T-Cell Lympho... Extracorporeal photopheresis (ExP) has been shown to be an efficacious and well-tolerated therapy in the treatment of cutaneous T-cell lymphoma...