Mouse in Biomedical ResearchLiu B, Shuai K. Cytokine-activated JAK-STAT signaling in the mouse immune system. In: Fox JG, Barthod SW, Davisson MT, et al., Eds. The mouse in biomedical research. 2nd ed. Burlington Academic Press 2007; pp. 179-93....
Cytokines are signaling molecules that coordinate complex immune processes and are frequently dysregulated in disease. While cytokine blockade has become a common therapeutic modality, cytokine agonism has had limited utility due to the widespread expression of cytokine receptors with pleiotropic effects. To...
However, they are probably best known for the roles they play in the immune system’s defense against disease-causing organisms. As part of the immune response, cytokines exert their influence over various white blood cells (leukocytes), including lymphocytes, granulocytes, monocytes, and macrophages...
Combined immunodeficiencies due to defects in signal transduction: defects of the gammac-JAK3 signaling pathway as a model. Combined immune deficiencies comprise a spectrum of genetic disorders characterized by developmental or functional defects of both T and B lymphocytes. Rec... LD Notarangelo,S...
- Interleukins are a family of cytokines involved in immune cells differentiation and activation. They mediate the traffic of immune cells to the site of the infection, induce the increase of the acute phase signaling, activate epithelial cells and mediate the production of secondary cytokines [21...
TGF beta signaling; Barrett's esophagus; Stem cell markers; Gastroesophageal reflux; Inflammation; 16.STAT3 in cancer: A double edged sword 机译:癌症中的stat3:双刃剑 作者:Lidia Avalle;Annalisa Camporeale;Andrea Camperi;Valeria Poli 期刊名称:《Cytokine》 | 2017年第2017期 关键词: STAT3; Can...
Provided herein are methods of detecting cytokine signaling responsiveness in immune cells from a cancer subject and determining risk of relapse of cancer in a subject. The methods include isolating cells from a blood sample from the cancer subject thereby forming an isolated blood cell fraction that...
Results We observed differences in immune cell subsets between lower‐ and higher‐risk IPSS groups with NKT cells, MDSCs, intermediate‐proinflammatory and non‐classical monocytes being higher in the latter group, while na?ve CD4+ T cells were reduced. Intermediate‐proinflammatory monocytes were ...
(IL)-6 and IL-10 cytokine expression and respective receptor signaling affecting T-cell functions in acute tuberculosis.Constitutive STAT3 phosphorylation,high expression of its key regulator suppressor of cytokine signaling(SOCS)3 and spontaneous IL-6/IL-10 secretion characterized CD4^(+)T cells ...
SOCS, SPRED, and NR4a: Negative regulators of cytokine signaling and transcription in immune tolerancedoi:10.2183/pjab.97.016Akihiko YOSHIMURADaisuke AKIMinako ITOProceedings of the Japan Academy, Series B Physical & biological sciences