Mouse in Biomedical ResearchLiu B, Shuai K. Cytokine-activated JAK-STAT signaling in the mouse immune system. In: Fox JG, Barthod SW, Davisson MT, et al., Eds. The mouse in biomedical research. 2nd ed. Burlington Academic Press 2007; pp. 179-93....
differentiation. Evidence is also emerging of the involvement of SOCS proteins in diseases of the immune system. In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell ...
Suppressor of cytokine signaling (SOCS) proteins are intracellular, cytokine-inducible proteins that inhibit cytokine signaling in numerous cell types, including cells of the immune and central nervous systems (CNS). From: Trends in Immunology, 2009 ...
IFN-γ diffuses extensively to alter the tumor microenvironment in distant areas. Using intravital imaging and a reporter for STAT1 translocation, we provide evidence that T cells mediate sustained IFN-γ signaling in remote tumor cells. Furthermore, tumor phenotypic alterations required several hours ...
Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol 2003;3:900-11 CrossRef Rane SG, Reddy EP. Janus kinases: components of multiple signaling pathways. Oncogene 2000;19:5662-79 CrossRef Velazquez L, Fellous M, Stark GR, Pellegrini S. A protein tyrosine kinase in ...
Once secreted, the cytokine binds to a specific protein molecule, called a receptor, on the surface of the target cell, an event that triggers a signaling cascade inside that cell. The signal ultimately reaches the nucleus, where the effects of the cytokine are manifested in changes in gene ...
storm, tissue damage, and acute respiratory distress syndrome. Here, we discuss the sensing of SARS-CoV-2 to induce innate immune activation and the contribution of this innate immune signaling in the development and severity of COVID-19. In addition, we provide a conceptual framework for ...
Analysis of the mucosal immune system of middle ear and nose in Suppressor of cytokine signaling (SOCS)-1 knockout mouse model with allergic rhinitis Suppressor of cytokine signaling 1 (SOCS1) is a negative feedback regulator of IL-4-dependent pathways in vivo and might therefore control T-hel...
Holmstrom TH, Schmitz I, Soderstrom TS, Poukkula M, Johnson VL, Chow SC, Krammer PH, Eriksson JE: MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly. Embo J. 2000, 19: 5418-28. 10.1093/emboj/19.20.5418. Article PubMed Central CAS...
Conclusion AhR signaling is involved in the lung leukocyte proinflammatory cytokine response to Cd. The relevance of the AhR to the cytokine response to Cd provides new insight into the mechanisms of Cd immunotoxicity. Keywords: Cadmium, Lung leukocytes, Aryl hydrocarbon receptor, Cytokine (IL...