The cytochrome P450 (CYP, P450) 2B subfamily has been well studied in rats, where it consists of four genes, two of which are highly inducible by phenobarbital (PB). In strong contrast, only one member of this subfamily has been identified in humans to date, namely CYP2B6. Until recently...
et al. Overexpression of a cytochrome P450 monooxygenase, CYP6ER1, is associated with resistance to imidacloprid in the brown planthopper, Nilaparvata lugens. Insect Mol Biol 20, 763–773 (2011). 36. Ding, Z. et al. Biochemical mechanisms of imidacloprid resistance in Nilaparvata lugens: over-...
P450 enzymes are best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The simple stoichiometry commonly describes the monooxygenase or mixed-function oxidase reaction of P450. (1)RH+O2+NADPH+H+→ROH+H2O...
plants, oomycetes and fungi has shown that P450s profiles in these organisms are affected by their lifestyle. However, the impact of lifestyle on P450 profiling in bacteria is scarcely reported.
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type takes place in the peroxisomes. InC. tropicalis,the first step in the ω-oxidation pathway is catalyzed by a membrane-bound enzyme complex (ω-hydroxylase complex) including a cytochrome P450 monooxygenase and a NADPH cytochrome reductase. This hydroxylase complex is responsible for the primary...
www.nature.com/scientificreports OPEN Structural diversity of anti- pancreatic cancer capsimycins identified in mangrove-derived received: 07 June 2016 Streptomyces xiamenensis 318accepted:08December2016 Published:18January2017 and post-modification via a novel cytochrome P450 monooxygenase He-Lin Yu1, ...
et al. Cytochrome P450 monooxygenase CYP53 family in fungi: Comparative structural and evolutionary analysis and its role as a common alternative anti-fungal drug target. PLoS ONE 9(9), e107209 (2014). 7. Moktali, V. et al. Systematic and searchable classification of cytochrome P450 proteins...
LUT1 encodes a cytochrome P450-type monooxygenase, CYP97C1. Introduction of a null mutant allele of LUT1, lut1-3, into the β-hydroxylase 1/β-hydroxylase 2 (b1 b2) double-mutant background, in which both Arabidopsis β-hydroxylases are disrupted, yielded a genotype (lut1-3 b1 b2) in...
Impact of lifestyle on cytochrome P450 monooxygenase repertoire is clearly evident in the bacterial phylum Firmicutes. Sci. Rep. 2020, 10, 13982. [Google Scholar] [CrossRef] Khumalo, M.J.; Nzuza, N.; Padayachee, T.; Chen, W.; Yu, J.-H.; Nelson, D.; Syed, K. Comprehensive ...