Although many studies have revealed the biochemical and physiological properties of the enzymes for ecdysteroid biosynthesis, most of the molecular identities of these enzymes have not been elucidated. Here we describe an uncharacterized cytochrome P450 gene, designated Cyp306a1, that is essential for ...
Cytochrome P450s, a class of lipid-modifying enzymes, are good candidates to be involved in the production or degradation of lipids essential for development. We investigated two highly similar cytochrome P450s in C. elegans, cyp-31A2 and cyp-31A3, that are homologs of the gene responsible ...
Cytochrome P450 enzymes are essential for the metabolism of many medications. Although this class has more than 50 enzymes, six of them metabolize 90 perce... T Lynch,A Price - 《American Family Physician》 被引量: 655发表: 2007年 Clinically important drug interactions potentially involving mechan...
Structures and functions of human placental aromatase and steroid sulfatase, two key enzymes in estrogen biosynthesis Cytochrome P450 aromatase (AROM) and steroid sulfatase (STS) are the two key enzymes for the biosynthesis of estrogens in human, and maintenance of the cri... D Ghosh - 《Steroid...
Cytochrome P450 monooxygenase-mediated detoxification is a very important mechanism of resistance to insecticides. In the LPR strain of house fly, the major mechanism of resistance to pyrethroids is monooxygenase-mediated metabolism due to the overexpression of cytochrome P450 6D1 (CYP6D1). Although th...
In plants, P450s are implicated in the formation of a broad range of metabolites, including the growth hormones gibberellins and jasmonates, essential components such as lignin, pigments, and fatty acids, and secondary metabolites such as alkaloids, phytoalexins, glucosinolates, phenylpropanoids, and...
As shown in Fig. 3, the total P450 activity in the R strain is 10.96-fold higher (p value < 0.0001) than that in the S strain. Taken together, these data suggest the enhanced expression of P450 genes results in higher level of P450 enzymes in the R strain which may ...
Entropy 2013, 15, 1416-1463; doi:10.3390/e15041416 Review OPEN ACCESS entropy ISSN 1099-4300 www.mdpi.com/journal/entropy Glyphosate's Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways ...
Their essential common feature is the absorbance peak near 450 nm of their FeII–CO complex for which they are named (Omura and Sato, 1964). P450 enzymes are best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the ...
The NADPH-cytochrome P450 Reductase Gene from Gibberella fukikuroi Is Essential for Gibberellin Biosynthesis. The fungus Gibberella fujikuroi is used for the commercial production of glbberellins (GAs), which it produces in very large quantities. Four of the seven ... Malonek,Stefan,Rojas,... -...