Cystic fibrosis (CF) is a genetic disorder, which means you get it from your parents at birth. It affects your lungs, pancreas, and other organs. CF changes the way chloride (salt) moves through the cells of your body. This causes the mucus (which should be thin and slippery) in vario...
Cystic fibrosis is one of the most common inherited metabolic disorders. In Austria, a child with the disease is born every 15th day. Every 20th child is a carrier of the causative gene without the onset of the disease. Causes A genetic defect of the 7th chromosome causes the so-called c...
Cystic fibrosis (CF) is a genetic disorder characterized by excessive exocrine gland activity, gastrointestinal malfunction, and progressive pulmonary disability (3, 9, 18). The basic defect is not known. However, factors have been found in the biological fluids of cystic fibrosis patients and ...
Cystic fibrosis (CF) is a fatal genetic disease primarily affecting Caucasians, although cases have been reported from other ethnic groups. CF has a complex etiology, but it is chiefly a disease of electrolyte transport and is characterized by defects in fluid secretion by several epithelia, ...
Cystic fibrosis is a genetic disorder that causes recurring lung infections and difficulty breathing. The disease is known for its sticky mucus buildup in the lungs, pancreas and other organs. Patients must use a variety of treatments to loosen mucus and ease breathing, including percussion vests ...
Cystic fibrosis is a genetic disease inherited as an autosomal recessive trait (14, 25, 32). The primary metabolic defect(s) remains unknown. In 1967 Spock et al. (40) described a rabbit tracheal ciliary dyskinesis factor found in the serum of CF patients. Since then, additional factors ...
Cystic fibrosis (CF) is a fatal genetic disease caused by abnormalities in fluid and electrolyte transport in exocrine epithelia. Both absorptive and secretory processes are affected by an underlying membrane defect in Cl- permeability. However, the impact of the defect on transport function is tissu...
Cystic fibrosis (CF) is a genetic disease caused by mutations in the CFTR gene that affect biosynthesis or activity of the protein at the levels of transcription, folding, trafficking, degradation, or channel opening. From:Annual Reports in Medicinal Chemistry,2014 ...
It is caused by a genetic defect in the cystic fibrosis transmembrane receptor (CFTR) gene, which creates the protein involved in the production of sweat, digestive fluids, and mucus. If there is a defect in this protein, it can lead to the abnormal accumulation of mucus in lungs, the blo...
Cystic fibrosis (CF) is an autosomal recessive disorder that is common in individuals of European descent. It is caused by mutations in the CFTR gene, which encodes the CF transmembrane conductance...