Steverding D, Caffrey CR, Sajid M (2006) Cysteine proteinase inhibitors as therapy for parasitic dis- eases: advances in inhibitor design. Mini Rev Med Chem 6, 1025-1032. PMID: 17018001D Steverding,CR Caffrey,M Sajid.Cysteine proteinase inhibitors as therapy for parasitic diseases: advances ...
Proteinase inhibitors of cereals andSolanaceaehave been investigated most extensively. Among the Solanaceae family, the greatest diversity of the inhibitor forms has been described in potato. Tubers of this plant were found to contain the inhibitors that suppress the activity ofserine, cysteine, andasp...
Of the many isoforms of the mammalian cysteine proteinase cathepsin, it is proposed that isoforms B and L might be involved in ulcerogenic and carcinogenic processes. On the other hand, the cysteine proteinases from C. candamarcensis described in this review, act as healers of chemically ...
α2 High molecular mass cysteine proteinase inhibitor: HMrα2-CPI: An inhibitor of human liver cathepsin H as probed by kinetic study HMrα2CPI was found to be an inhibitor of human liver cathepsin H by the measurement of the dissociation constant (Ki), the association rate constant (k1) ...
Papain-like cysteine proteases (PLCPs), a large group of cysteine proteases structurally related to papain, play important roles in plant development, senescence, and defense responses. Papain, the first cysteine protease whose structure was determined by X-ray crystallography, plays a crucial role ...
The involvement of a cysteine proteinase in the nodule development in Chinese milk vetch infected with Mesorhizobium huakuii subsp. rengei. Plant Physiol. 2000, 124, 1087–1096, doi:10.1104/pp.124.3.1087. [29] Lievens, S.; Goormachtig, S.; Holsters, M. Nodule-Enhanced protease inhibitor ...
Cysteine proteinases are a subclass of endopeptidases which require activation by thiol reagents. A tumor cysteine proteinase which appears to be related t
Evolutionary features of cystatins inT. urticae.(A) Phylogram ofT. urticaecystatin sequences showing the presence of functional conserved residues in the four cystatin groups deduced from the phylogenetic tree. Amino acid sequences responsible of the inhibitor-C1A enzyme interaction are shaded in green...
Cysteine proteases, expressed as pre-proteins, consist of an I29 inhibitor domain preventing non-specific activity [27]. In our study, transcription of the entire set of nodule VPE cysteine proteases strongly increased coinciding with the progression of senescence. VPEs are therefore predominantly ...
In the present study, we report for the first time that cysteine proteinase inhibitors decrease osteoclast formation. We have demonstrated that cystatin C, a 13.4-kDa protein inhibitor of cysteine proteinases expressed in both osteoblasts and osteoclasts, inhibits the formation of TRAP+ OCL in mouse...