Several CPs have been isolated from a number of plant sources, like papain, actinidin, proteinase Ω, chymopapain, stem bromelain and mexicain. Most of them belong to the papain and legumain families (Grudkowska and Zagdanska, 2004). The best-known CPs are caspase-like proteins, vacuolar-...
The use of plants as natural sources of novelantiprotozoalcompounds has contributed to developantiparasitic drugs.87,163Natural products that displayedantiprotozoal activitywere screened against human proteinasescathepsin Land B, andL. mexicanacathepsin L like rCPB2.8 proteinase for the discovery of novel...
pisum were correlated with a decrease of cathepsin B- and L-like proteinase activities. In the case of M. persicae, there was an increase of these proteolytic activities, but also of the aminopeptidaselike ...
Cysteine proteases, expressed as pre-proteins, consist of an I29 inhibitor domain preventing non-specific activity [27]. In our study, transcription of the entire set of nodule VPE cysteine proteases strongly increased coinciding with the progression of senescence. VPEs are therefore predominantly ...
However, the great majority of truncated cruzipain genes, at least so in Dm28c and YC6 strains, retain intact the signal peptide and the prodomain, which could result in the production of proteins without enzymatic activity, but retaining a functional prodomain, that acts as an inhibitor of ...
Poliovirus proteinase 3 C: large-scale expression, purification and specific cleavage activity on natural and synthetic substrates in vitro. J. Virol. 62, 4586–4593 (1988). CAS PubMed PubMed Central Google Scholar Han, Y. S. et al. Papain-like protease 2 (PLP2) from severe acute ...
Amino acid sequence of an inducible cysteine proteinase inhibitor (cystatin) from submandibular glands of isoproterenol-treated rats. We have previously reported the purification of an inducible cysteine proteinase inhibitor from submandibular glands of isoproterenol-treated rats by seque... GS Bedi - 《...
As expected, activity of both of the recombinant EnCLs was inhibited by the general papain-like cysteine peptidase inhibitor E-64. Surprisingly, however, the iCL, a highly potent amphiphilic reversible peptide inhibitor of human cathepsin L [65], had but a little effect on the enzymes’ activit...
Inhibitor of κB kinase Janus kinase JNK c-Jun amino-terminal kinase Kelch-like ECH-associated protein 1 Lamp-2A Lysosome-associated membrane protein type 2A l-DOPA l-3,4-Dihydroxyphenylalanine LID l-DOPA-induced dyskinesias Lipopolysaccharide Leucine-rich repeat kinase 2 MAO Monoamine oxidase Mitoge...
Evolutionary features of cystatins inT. urticae.(A) Phylogram ofT. urticaecystatin sequences showing the presence of functional conserved residues in the four cystatin groups deduced from the phylogenetic tree. Amino acid sequences responsible of the inhibitor-C1A enzyme interaction are shaded in green...