CYP3A4 其他CYP酶: CYP2B6 CYP2C8 ADME产品链接:https://www.iphasebio.com/?p=4&cateid=555 探针底物(Probe substrate): 非那西丁(CYP1A2)、香豆素(CYP2A6)、安非他酮(CYP2B6)、紫杉醇(CYP2C8)、甲苯磺丁脲/双氯芬酸钠(CYP2C9)、奥美拉唑(CYP2C19)、美芬妥因(CYP2C19)、右美沙芬(CYP2D6)、氯唑...
As confirmed by Le Carpentier I et al i ., we have shown that the metabolism of midazolam, a CYP3A4/5 substrate, is decreased in patients hospitalized with SARS-CoV-2 infection and is inversely associated with CRP levels. Impact of SARS-CoV-2 infection (COVID-19) on cytochromes P45...
CYP3A4 探针底物/Probe substrate: 非那西丁(CYP1A2) 香豆素(CYP2A6) 安非他酮(CYP2B6) 紫杉醇(CYP2C8) 甲苯磺丁脲(CYP2C9) 奥美拉唑(CYP2C19) 美芬妥因(CYP2C19) 右美沙芬(CYP2D6) 氯唑沙宗(CYP2E1) 咪达坐仑 midazolam(CYP3A4) 睾酮(CYP3A4) ...
药物代谢酶调控与生物学效应 中国医学科学院中国协和医科大学药物研究所李燕 内、外源物体内生物转化途径 PhaseII(GST,UDPGT)XenobioticsEndobiotics PhaseI (CYP450)OxidationReductionHydrolysis Conjugate PhaseII(GSH,UDPGA,SO42-)Metabolite Excreted CytotoxicityMutagenicityCarcinogeneci 药物代谢酶的种类及命名 细胞...
酮康唑(CYP3A4) 体外代谢抑制剂 CYP450酶(细胞色素P450酶): CYP1A2 CYP2A6 CYP2B6 CYP2C8 CYP2C9 CYP2C19 CYP2D6 CYP2E1 CYP3A4 探针底物/Probe substrate: 非那西丁(CYP1A2) 香斗素(CYP2A6) 安非他酮(CYP2B6) 紫杉醇(CYP2C8) 甲苯磺丁脲(CYP2C9) 奥美拉唑(CYP2C19) 美芬妥因(CYP2C19) 右美沙...
Methods: Oleanolic acid or ursolic acid was incubated together with CYP probe substrate in human liver microsomes, the inhibition ratio (IQ) was calculated by comparing the inhibition for different concentrations of oleanolic acid with the different concentrations of midazolam (substrate of CYP3A4). ...
『关键词]UPLC.MS/MS;细胞色素P450酶;大鼠【中图分类号]TQ [文献标识码】A [文章编号]1007.1865(2021)13—0067—04Establishment and Verification ofSeven CYP450 Enzyme Substrate Analysis Methods in Biological SamplesSu Junl,Liu Yuzhen 2,Hong Lili2(1.Department ofPharmacy,the FirstAffiliated Hospital of...
alargenumberofstudieshaveshownthatP-gpplaysaroleintheoxidativemetabolismofitssubstratesthatarealsosubstratesofCYP3A4.CombinedactionsofP-gpandCYP3Acouldaccountinsomepartfortheloworalbioavailabilitydeterminedformanyofthesedualsubstrates.P-gpalongwitheffluxtransporters(MRPandBCRP)havingoverlappingsubstratespecificityplays...
探针底物/Probe substrate: 非那西丁(CYP1A2) 香豆素(CYP2A6) 安非他酮(CYP2B6) 紫杉醇(CYP2C8) 甲苯磺丁脲(CYP2C9) 奥美拉唑(CYP2C19) 美芬妥因(CYP2C19) 右美沙芬(CYP2D6) 氯唑沙宗(CYP2E1) 咪达坐仑 midazolam(CYP3A4) 睾酮(CYP3A4) ...
(存在、含量、抑制酶反应、作用机制) Multiple forms of CYP450 (separation, purification, substrate specificity, quantitation) Gene cloning, P450cam, regulation.(活性中心) 2000 papers/year, 转录因子、受体、aa 改变-底物特异性和种属差异, 人基因 多态性 药物代谢药物代谢 I I 相酶相酶CYP450CYP450 (二...