Recombinant Human CYP3A4 Enzyme CYP/EZ002 CYP3A4 + 还原酶 CYP3A4 + reductase 0.5nmol P450 at 1nmol/ml, 10mg/ml protein CYP450酶,CYP450酶代谢底物,代谢产物及相关抑制剂,可用于体外药物代谢稳定性、代谢表型等研究。体外代谢研究可直接观察候选化合物与受试靶点的选择性作用,不需要消耗大量的样品和实验...
CYP3A4(CYP450重组酶) 更多供应商 汇智和源生物技术(苏州)有限公司 联系电话: 010-59755330 13701268334 产品介绍: 中文名称:CYP3A4(CYP450重组酶) 英文名称:Recombinant Human CYP3A4 Enzyme 包装信息:1mol/RMB 10 最新发布供应信息 CYP3A4(CYP450重组酶)￥10mol汇智和源生物技术(苏州)有限公司2024/11/07 ...
enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. ...
steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved
细胞色素P450酶属于血红素-硫醇盐蛋白的超基因家族,可介导临床约90%的药物代谢[1-2],其活性及表达量的变化直接影响其底物在体内的生物转换[3-4],是许多药物发生疗效改变、毒性反应及药物间相互作用的原因之一[5-6]。细胞色素P450 3A4酶(cytochrome P450 3A4 enzyme,CYP3A4)作为细胞色素P450酶家族中重要成员,在...
Enzyme-linked Immunosorbent Assay: 1:100-200 Optimal working dilutions must be determined by end user.细胞色素P450家族成员3A4(CYP3A4)多克隆抗体 [ IMAGES ] [ CONTENTS ] Form & Buffer: Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol. ...
大鼠细胞色素P450家族成员3A4(CYP3A4/CYP3A3) ELISA试剂盒是典型的夹心法酶联免疫吸附测定试剂盒(Enzyme-Linked Immunosorbent Assay,ELISA),采用双抗体夹心ELISA法。预先包被的抗体为细胞色素P450家族成员3A4(CYP3A4/CYP3A3) 单克隆抗体,检测相抗体为多克隆抗体,经生物素(biotin)标记。样品和生物素标记抗体先后加入...
There is substantial interindividual variability in CYP3A4 enzyme activity because of genetic variability, environmental factors, disease state, and comedications (ie, induction and inhibition) (https://medicine.iu.edu/internal-medicine/specialties/clinical-pharmacology/drug-interaction-flockhart-table, last...
It is an extremely important enzyme for drug metabolism; CYP3A4 catalyzes phase I oxidation reactions in an estimated 60% of all clinically used drugs, promoting in most cases their clearance by excretion. CYP3A4 levels are induced by glucocorticoids and various xenobiotics, including drugs, ...
The invention provides a novel cytochrome CYP3A4 enzyme specific probe reaction and an application thereof; gomisin A can be used as a probe substrate of a CYP3A4 enzyme for detecting the activity of the enzyme; the gomisin A or a pharmaceutical preparation thereof is used as the specific ...