CYP2D6 Inhibitors Concurrent use of CYP2D6 inhibitor medications may decrease or prevent the conversion of opioid medications to morphine. Therefore, we excluded participants who were prescribed a medication that was a strong or moder- ately strong inhibitor of CYP2D6.24 The list of inhibitors ...
In contrast, endoxifen plasma concentrations are up to 10- fold higher than 4HT, exhibiting substantial variability.17,22,30 Patients with low CYP2D6 enzyme activity, as a result of CYP2D6 genetic polymorphisms or the coadministration of strong CYP2D6 inhibitors, exhibit significantly lower ...
of tamoxifen, and none were reported as receiving CYP2D6 inhibitors. For this literature review, PMs were defined in terms of the presence of two nonfunctional alleles. Although no consen- sus exists in this regard, for the purposes of this review we defined IMs as those having two decreased...
CYP2D6 substrate drugs including antidepressants, selective serotonin-reuptake inhibitors, antiemetics, beta-blockers, and opioids are mostly lipophilic in nature [13–15]. To date, more than one hundred CYP2D6 alleles and sub-variants are available at the human CYP allele nomenclature website [16...