Therefore, we excluded participants who were prescribed a medication that was a strong or moder- ately strong inhibitor of CYP2D6.24 The list of inhibitors considered for this study is shown in Table S2. Because most of these prescriptions are intended to be taken long term, we considered ...
et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 genotypes and dosing of selective serotonin reuptake inhibitors. Clin. Pharmacol. Ther. 98, 127–134 (2015). 6. CPIC. CPIC Guideline for Tamoxifen based on CYP2D6 genotype. . 7. Goetz, M.P. ...
A list of inhibitors that was considered for this study is shown in Table S3. Because most of these prescriptions are intended to be taken long term, we considered persons exposed to a CYP2D6 inhibitor if the prescription occurred within 1 year prior to the opioid prescription. Analyses The ...
While a statically significant difference in bradycardia between CYP2D6 NMs and PMs was found, CYP2D6 major inhibitors did not produce the same effect in this study. Additional research into the impact of CYP2D6 phenoconversion and the role drug–drug interactions play on metoprolol is also needed...