Fifty-nine (6.5%) patients were users of CYP2D6 inhibitors (median duration, 23months). DFS at 3years (corresponding to 5years after tamoxifen initiation) did not differ between users and non-users of CYP2D6 inhibiting drugs (92.7 vs. 93.0%, respectively; adjusted P =0.44). OS at 3years...
CYP2D6-inhibiting drugs and the increased risk of fall-related injuries due to newly initiated opioid treatment - a Swedish, register-based case-cross- ... J Möller,L Laflamme,KS Löfdal - 《Basic & Clinical Pharmacology & Toxicology》 被引量: 9发表: 2015年 CYP2D6-Inhibiting Drugs and...
Consideration should also be given to discontinuing CYP2D6 inhibitors and allowing sufficient time for the enzyme to regenerate (up to 2 weeks) before LSD is used. Alternatively, in the presence of CYP2D6 inhibitors, the dose of LSD should be reduced, based on the present findings. On the ...
CYP2D6 is an important member of CYP family that is responsible for metabolism in hepar, which mainly involved in tricyclic antidepressants, anti-arrhythmic drugs, antipsychotics, antipyretic analgesics, narcotic, β -adrenergic receptor blockers, selective serotonin reuptake inhibitors, nerve sedative ...
Since its discovery, many have intensively studied this unique hemoprotein and contributed to the elucidation of its molecular properties and physiological functions and also the structure-activity relationships of its substrates and inhibitors. Its activity ranges considerably within a population due to ...
However, no information was available indicating drug interaction between and inhibitors of . The aim of this... N Yasui-Furukori,M Saito,Y Inoue,... - 《European Journal of Clinical Pharmacology》 被引量: 49发表: 2007年 Effects of the CYP2D6*10 alleles and co-medication with CYP2D6-...
For those drugs that are metabolized by CYP2D6 to inactive metabolites, CYP2D6 inhibitors may result in toxicity. For drugs that are converted to active metabolites by CYP2D6, the addition of a CYP2D6 inhibitor will tend to inhibit the efficacy of the drug. Genetic variability in CYP2D6 ...
CYP2D6 Inhibitors Drugs that inhibit CYP2D6 activity are likely to increase the plasma concentrations of certain medications, and, in some cases, adverse outcomes will occur (see Table 3 below right for a list of known inhibitors). Some drugs, such as fluoxetine, paroxetine, and quinidine, are...
Crewe HK, Lennard MS, Tucker GT, Woods FR, Haddock RE. The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. British Journal of Clinical Pharmacology 34: 262–265, 1992
Response to treatment with selective serotonin reuptake inhibitors (SSRIs) varies considerably between patients. The International SSRI Pharmacogenomics Co... JM Biernacka,K Sangkuhl,G Jenkins,... - 《Translational Psychiatry》 被引量: 53发表: 2015年 Important and critical scientific aspects in pharma...