Selected inducers, inhibitors and substrates of CYP2D6[6] Substrates Inhibitors Inducers Often mentioned: [7] beta-blockers metoprolol carvedilol timolol Class I antiarrhythmics flecainide lidocaine propafenone encainide mexiletine All tricyclic antidepressants, e.g. imipramine amitriptyline etc. ...
CYP2D6 Inducers The evidence suggests that, unlike most other CYP450 enzymes, CYP2D6 is not very susceptible to enzyme induction. Thus, genetics, rather than drug therapy, accounts for most ultrarapid CYP2D6 metabolizers. Drugs Activated by CYP2D6 Codeine Codeine is largely a prodrug, and its ...
fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug- interactions-table-substrates-inhibitors-and-inducers#table3-2. Accessed March 7, 2020. 25. Drewes AM, Jensen RD, Nielsen LM, et al. Differences between opioids: pharmacological, experimental, clinical and economical perspectives. ...
Available online: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug-interactions-table-substrates-inhibitors-and-inducers (accessed on 16 September 2022). Shin, J.; Hills, N.K.; Finley, P.R. Combining Antidepressants with β-Blockers: Evidence of a Clinically ...