The CYP2D6 gene encodes cytochrome P450 2D6, an enzyme that plays a crucial role in the metabolism of all tricyclic antidepressants, most SSRIs, and about half of all antipsychotics. Inter-individual variability in the function of this enzyme largely stems from polymorphisms, gene copy number ...
Its metabolism involves the phase I enzyme, cytochrome P4502D6 (CYP2D6), encoded by the highly polymorphic CYP2D6 gene. CYP2D6 variants resulting in poor metabolism of tamoxifen are hypothesised to reduce its efficacy. An FDA-approved pre-treatment CYP2D6 gene testing assay is available. However,...
参考文献:1.ZangerUM,SchwabM.CytochromeP450enzymesindrugmetabolism:regulationofgeneexpression,enzymeactivities,andimpactofgeneticvariation.Pharmacology&Therapeutics,2013,138(1):103-141.2.WilffertB,SwenJJ,MulderH,etal.FromPGxtestingtoPrecisionMedicine-APublicHealthPerspective.FrontiersinPersonalizedMedicine,2021,1(1...
Variants in the CYP2D6 gene can cause patients to be either intermediate or poor metabolizers, thereby rendering tamoxifen treatment less effective. Testing for CYP2D6 gene variants is available in Clinical Laboratory Improvement Amendments–certified clinical labora- tories; however, the biological ...
Interethnic differences in allele frequency distribution of the CYP2D6 gene are well established, but interethnic admixture, introducing variations in population ancestry and resulting in distinct levels of population structure, should be acknowledged in pharmacogenomic studies to avoid inappropriate ...
Since the first description of a CYP2D6 sparteinedebrisoquine polymorphism in the mid-seventies, substantial genetic heterogeneity has been reported in the human CYP2D6 gene, with ~100 different polymorphisms identified to date. Some of these polymorphisms render the enzyme completely inactive while ...
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacology & Therapeutics, 2013, 138(1): 103-141. 2. Wilffert B, Swen JJ, Mulder H, et al. From PGx testing to Precision Medicine- A Public Health Perspective. ...
The activity of CYP2D6 varies widely between individuals, mainly due to the presence of a large number of functionally important allelic variants of the CYP2D6 gene. About 1% of Caucasians carry two CYP2D6 alleles causing lack of enzyme activity (poor metabolizers, PM). In the other extreme,...
[41] and theSMN1gene [29] responsible for spinal muscular atrophy. The method employed in Cyrius can be applied to resolve other paralogs that suffer from the same homology problem. We are currently extending this method to genotype other pharmacogenes with a paralog,CYP2A6, andCYP2B6, and ...
The CYP2D6 gene determines oxycodone's phenotype-specific addictive potential: Implications for addiction prevention and treatment - Medical Hypotheses We propose a hypothesis for predicting addictive potential of oral drugs, in general, and oxycodone's addictive potential, in particular. We hypothesize th...