PurposeWhen codeine and tramadol are used for pain management, it is imperative that nurses are able to assess for potential drug-gene and drug-drug-gene interactions that could adversely impact drug metabolism and ultimately pain relief. Both drugs are metabolized through the CYP2D6 metabolic ...
CYP2D6_10等位基因特性对临床用药安全性和有效性的影响
The cytochrome P450 2D6 (CYP2D6) is an enzyme known to metabolize a variety of xenobiotics and drugs. Inter‐individual variation in the metabolic capacity of this enzyme has been extensively studied and associations with genotype have been established. Genetic polymorphisms have been grouped as non...
There is significant variation in the response of individuals to a large number of clinically prescribed drugs. A strong contributing factor to this variability in drug metabolism is the genetic composition of the drug-metabolizing enzymes, and thus genotyping pharmacogenes is important for personalized ...
steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. Th...
CYP2D6‐Inhibiting Drugs and the Increased Risk of Fall‐Related Injuries Due to Newly Initiated Opioid Treatment – A Swedish, Register‐Based Case‐Crossover Study CYP2D6-inhibiting drugs and the increased risk of fall-related injuries due to newly initiated opioid treatment - a Swedish, register...
阿片类药物被广泛用于中度至重度疼痛的治疗,然而其镇痛效果及不良反应存在广泛的个体差异。药物遗传学研究表明,基因多态性与上述个体差异有密切关系,研究较多的为CYP2D6、 μ阿片受体(OPRM1)和儿茶酚-O-甲基转移酶(COMT)等基因的多态性。2021年2月,临床药物遗传学实施联盟(CPIC)发布了《根据CYP2D6、OPRM1和COMT基因...
随访至第 8 周的临床疗效进行分 析,结果表明不同代谢型第 8 周总体有效率存在显 著差异.目前尚无研究考察 CYP2D6 代谢型对阿立 哌唑治疗抽动障碍患儿临床疗效的影响.张璇等[24] 在 84 例精神分裂症患者中考察 CYP2D6 基因多态 ·1188· 第 39 卷第 5 期 2024 年 5 月 现代药物与临床 Drugs & Clinic...
本文就其基因多态性对临床常用药物的影响作一概述。【关键词】 细胞色素 P4502D6 ;基因多态性 ;临床用药DOI :10.14164/j.cnki.cn11-5581/r.2019.16.134Effect of CYP2D6 gene polymorphism on drugs commonly used in clinic LI Juan, QIU Fu-rong. Shanghai University of Traditional Chine......
PurposeWhen codeine and tramadol are used for pain management, it is imperative that nurses are able to assess for potential drug-gene and drug-drug-gene interactions that could adversely impact drug metabolism and ultimately pain relief. Both drugs are metabolized through the CYP2D6 metabolic pathwa...