(2005). CYP2D6 gene deletion allele in patients with neuroleptic malignant syndrome: Preliminary report. Psychiatry Clin Neurosci 59:504-507.Kato,D,Kawanishi,C,Kishida,I,Furuno,T,Matsumura,T,Hasegawa,H,Suzuki,K,Hirayasu,Y.CYP2D6 gene deletion allele in patients with neuroleptic malignant syndrome...
The CYP2D6*5 (gene deletion) and CYP2D6*UM (gene duplication) variants were identified using a biplex Taqman real-time quantification assay as per the Schaeffeler and colleagues protocol [45]. Samples from patients with the known genotype CY2D6*1/*1 (EM or wild-type variant) were used ...
(12), CYP2D6*5 (gene deletion) was determined based on the method of Hersberger et al. (13), CYP2D6 gene duplication was analyzed according to Lovlie et al. (14). Genotyping analyses were classified using the CYP2D6 activity score (0, 0.5, 1, 1.5, 2, Ͼ2) (2,9). Patients in...
CYP2D6 gene deletion (allele *5) and duplication/multiplication (allele *xN) were determined using a TaqMan Copy Number Assay (Hs04502391_cn). Activity scores for CYP2D6 were assigned according to established guidelines10,12,32,33,34. To see a distinct effect of CYP2D6 functionality on the ...
The invention belongs to the field of biology, and relates to a single base deletion mutant of CYP2D6 allele 1995th site. The base C at the site is deleted. The invention particularly relates to a nucleic acid segment containing the mutant site and a corresponding coded protein segment thereof...
[4] MeijermanI,SandersonLM,SmitsPH,eta1.Pharmaco— 目前研究 CYP2D6基因CNVs的技术主要是基于 geneticscreeningofthegenedeletion andduplicationsof 芯片杂交 ’ 。常用的是 比较基因组杂交技术 CYP2D6[J].DmgMetabRev,2007,39:45—60. 协和 医学 杂志 [5] 陈执 中.人类基因组拷贝数变异与新药研究开发 ...
Currently, more than 63 different functional CYP2D6 gene variants have been described. Among them, the most important variants are CYP2D6*4 (splice defect) and CYP2D6*5 (gene deletion), whereas the common alleles with severely reduced activity are CYP2D6* 10, CYP2 D6* 17, and CYP2D6*4 ...
modified from Hick et al17 (Table 2) showed that the frequencies of CYP2D6 allele with nonfunctional enzyme activity, that is, CYP2D6*3, *4, and *5 (gene deletion), are higher in Caucasian, Ameri- can, African, and Middle East population and also found high allelic frequency in South...
Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology. The cytochrome P450 enzyme debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as antidepressants and neuroleptics. ... VM Steen,OA Andreassen,AK Daly,... ...
Pharmacogenetic screening of the gene deletion and duplications of CYP2D6. Cytochrome P450 (CYP) 2D6 is one of the most important enzymes involved in the metabolism of drugs. Multiple, clinically relevant, genetic variants of this... I Meijerman,LM Sanderson,PHM Smits,... - 《Drug Metabolism ...