The allele CYP2D6*5, consisting of a gene deletion, is representative of a missing enzymatic activity [20]. Following the Activity Scores (AS) results, in which NM are assigned a value of 2, with decreased activity alleles ranging from 0.25 to 1.5, no enzymatic activity assigned a score of...
CYP2D6*5 represents deletion of the CYP2D6 gene and its frequency is larger than 1% in the Taiwanese population. Theoretically, the genotype frequency of homozygous CYP2D6*5 is about 0.3% (0.0552) and represents the PM phenotype. However, we could not find homozygous CYP2D6*5 in this study...
Gultathione S-transferase M1 gene deletion may be associated with susceptibility to certain forms of schizophrenia Biochem. Biophys. Res. Commun. (2001) E. Lundqvist et al. Genetic mechanisms for duplication and multiduplication of the human CYP2D6 gene and methods for detection of duplicated CYP...
(wt) alleles; 2) comparable levels of CYP2C19 inCYP2C19*2/*17andCYP2C19*1/*2individuals; 3) reduced CYP2D6 protein levels in heterozygous individuals with theCYP2D6*3,CYP2D6*4, andCYP2D6*5 gene deletion variants; and 4) significantly lower levels of CYP3A5 protein inCYP3A5*3 homozygous ...
Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype The human CYP2D6 gene codes for the enzyme, debrisoquine 4-hydroxylase, which metabolizes over 25 therapeutically important drugs. The inability to metabol....