CYP2D6*4 Reference Standard询价 产品描述 产品数据库 CBPA0083 Format Genomic DNA Description CYP2D6, cytochrome P450 family 2 subfamily D member 6, is a member of the cytochrome P450 family of monooxygenases that catalyzes drug metabolism (PMID: 28480783). CYP2D6 variants have been associated ...
名称CYP2D6*4 Reference Standard 型号CBPA0004 报价 特点CYP2D6*4 Reference Standard 详细内容 CBPA0004 FormatGenomic DNA DescriptionCYP2D6, cytochrome P450 family 2 subfamily D member 6, is a member of the cytochrome P450 family of monooxygenases that catalyzes drug metabolism (PMID: 28480783). CYP2D6...
Homozygous CYP2D6*4 frequency was significant lower in breast cancer patients than in the control group (OR=0.22, p=0.04). The heterozygous CYP2D6*4 group also displayed lower values in patients than in controls but the difference was not significant (OR=0.698, p=0.28). Therefore, the presen...
CYP2D6 gene is located on chromosome 22q13.1.The most frequent inactivating mutation among Caucasians is the splice site G1934A transition (CYP2D6*4 allele) that cause a truncated protein. G to A transition at the intron3/exon4 boundary of the CYP2D6 gene leads to incorrect splicing of ...
CYP2D6基因检测是指通过检测cytochrome P450 2D6 (CYP2D6)基因,来确定药物代谢的速度和效果的检测。CYP2D6是一种脂质合成酶,是药物代谢的重要分子,它可以转化大多数类精神类和抗病毒药物,从而决定药物的有效性和效果。 CYP2D6基因检测是个小分子筛查技术,可以发现在某一特定基因当中特定等位基因变异发生的情况。根据...
DPWG指出,在抗精神病药物治疗前进行基因分型,可根据阿立哌唑、依匹哌唑、氟哌啶醇、匹莫齐特、利培酮和珠氯噻醇与CYP2D6的相互作用以及喹硫平与CYP3A4的相互作用等,进行个体化用药方案的调整。 安智因精神神经系统个体化用药基因检测项目介绍 安智因推出了基于MassARRAY核酸质谱分析系统的精神神经系统个体化用药基因检测项...
Aim:The aim of this study was to investigate the associations between theCYP2D6*4polymorphism, interindividual differences inCYP2D6activity and adverse drug effects in postherpetic neuralgia (PHN) patients receiving tramadol.Patients & methods:The study comprised 158 patients (including 78 nonresponders ...
CYP2D6酶是P450家族中重要成员,研究表明CYP2D6参与了30%以上的药物代谢,如神经精神类药物帕罗西叮、阿立哌挫、氯氮平等。精神类药物反应的个体差异大,其中59%的药物不良反应与基因型相关。美国FDA批准的药品说明书中有200多种药物被建议进行基因检测,其中精神疾病类药物...
1.黄芩素与CYP3A4和CYP2D6的相互作用:研究表明,黄芩素能够抑制CYP3A4的活性,进而影响某些底物的代谢。同时,黄芩素还能与CYP2D6相互作用,增强其代谢能力。 2.槲皮素与CYP3A4的相互作用:槲皮素对CYP3A4具有诱导作用,可提高其活性,从而加速某些药物的代谢。 3.芦丁与CYP3A4和CYP2D6的相互作用:芦丁主要与CYP3A4相...
dna中cyp 2d6基因 c188t位点的多态性. 细胞色素p450 2d6 2d6(cyp2d6 )是人体中重要的药物代谢酶之一而其基因多态性是引起个体间和种族间对同一药物表现出不同代谢能力的重要原因之一.cyp2d6基因在不同种族间发生多态性的位点存在明显差...