在讨论CYP2D6*10突变位点时，常见的表示方式如C188T和C100T均不完整。准确的表述应当以rs号作为唯一标识。然而，在实际操作中，公司可能不会在材料中明确列出rs号。对于CYP2D6*10的具体位点，正确的表示方式为c.100C＞T。通过NCBI-Clinvar数据库查询，可以得知该突变为NM_000106.6(CYP2D6):c.100C...
①一般来说C188T和C100T这种写法都不完整。rs号是SNP的唯一代码。但是一般公司在编材料的时候都不把rs...
CYP2D6*10 (rs1065852)位点基因分型Taqman探针结果如图1。 图1 CYP2D6*10(c.100 C>T)位点基因分型Taqman探针结果 Fig.1 Result of CYP2D6*10 (c.100 C>T) genotyping by Taqman PCR. A: Amplification plot of CYP2D6*10 (c.100 C>T) CC genotype; B: Amplification plot of CYP2D6*10 (c.100...
rs equenc i ngr e su l twa s100%. Conc l u s i on Thee s G yr t ab l i shedCYP2D6∗10f l uo r e s c en tquan t i t a t i vePCRde t e c t i ons t emexh i b i t sh i c cu r a c ens i t i v i t ys gha yands y, andha sawi der angeo fapp...
实现CYP2D6(rs1065852)的基因分型。 权利要求书1页说明书4页 序列表1页附图2页 CN112695097B 2022.08.19 C N 1 1 2 6 9 5 0 9 7 B 1.一种用于区分假基因CYP2D7P和CYP2D8P从而扩增和分型CYP2D6*10遗传多态性的引 物探针组合,其特征在于:所述引物探针组合包括以下引物和探针:引物:CYP2D6‑F:5...
The CYP2D6*10 gene variant (rs1065852C>T) is reported to be commonly found in Asian and South Asian populations. The present study was undertaken to design a novel pharmacogenetic assay (Single step-Tetra Arms Polymerase Chain Reaction) for the identification of the CYP2D6*10 variant and ...
We determined the relative catalytic activities of CYP2D6*1 and CYP2D6*10 for metabolizing AMMC and bufu- ralol and gained an understanding of the effects of the inhibi- tors on the variants of CYP2D6. In the initial screening study, six phytochemicals competitively inhibited CYP2D6*1- and ...