Cytochrome P450 2C19 (abbreviated CYP2C19), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. It is involved in the metabolism of several important groups of drugs including many proton pump inhibitors and antiepileptics. ...
Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis. Am J Cardiol. 2009;103(6):806-81119268736PubMedGoogle ScholarCrossref 27. Harmsze AM, van Werkum JW, Souverein PC, et al. Combined influence of proton-pump inhibitors, ...
Martin de Argila C. Safety of potent gastric acid inhibition.Drugs2005;65(Suppl 1): 97-104 PubMedWeb of Science ®Google Scholar Aseeri M, Schroeder T, Kramer J, Gastric acid suppression by proton pump inhibitors as a risk factor for clostridium difficile-associated diarrhea in hospitalized ...
For CYP2C9, these include several widely prescribed medications such as antifungals and phenytoin,2 whereas many antidepressants,3 anitfungals,4 proton pump inhibitors,5 and the antiplatelet medication clopidogrel6 are metabolized by CYP2C19. Many pharmacogene haplotypes, including those for CYP2C8,...
dosing guidelines for drugs such as clopidogrel, tricyclic antidepressants, and selective serotonin-reuptake inhibitors have been established based onCYP2C19genotypes [25,26,27,28]. Identifying the genetic variation ofCYP2C19is an important factor in the dose adjustment for PPIs and might therefore improv...