The objective of this study was to extend this method to drug interactions caused by CYP1A2 inhibitors and inducers. Methods First, initial estimates of the model parameters were obtained using data from the literature. Then, an external validation of these initial estimates was performed by ...
"Inhibitory effect of grapefruit juice and its bitter principal, naringenin, on CYP1A2 dependent metabolism of caffeine in man". Life Sciences 59 (13): 1025-1030. PMID 8485024.Meijerman I, Beijnen J, Schellens J. "Herb-drug interactions in oncology: focus on mechanisms of induction". ...
Department of Clinical Pharmacology University of Helsinki Finland Interactions of tizanidine with CYP1A2 enzyme inhibitors Studies in vitro and in humans Marika Granfors Academic Dissertation To be presented, with the permission of the Medical Faculty of the University of Helsinki, for public examinatio...