Can cause fetal harm; advise patients of the potential risk to a fetus and to use effective nonhormonal contraception Drug interaction overview Tazemetostat is a CYP3A4 substrate and CYP3A4 inducer Strong and moderate CYP3A inhibitors Avoid coadministration ...
Antiplatelet agents, including vorapaxar, increase the risk of bleeding, including ICH and fatal bleeding (see Black Box Warnings) Strong CYP3A inhibitors increase and inducers decrease vorapaxar exposure; avoid coadministration Pregnancy and Lactation Based on the potential for serious adverse reactions (...
aCaution should be used when administering or taking TARCEVA with ketoconazole and other strong CYP3A4 inhibitors such as, but not limited to, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, troleandomycin (TAO), voriconazole and grapefr...
RIC8A (Resistance to Inhibitors of Cholinesterase 8 Homolog A (C. elegans), MGC104517, MGC131931, MGC148073, MGC148074, RIC8, synembryn) (MaxLight 750)Details MCPH1 (microcephalin 1, BRIT1, FLJ12847, MCT) (APC)Details BIN3 (bridging integrator 3, MGC14978) (HRP)Details ...
Clinical Impact: Decreased exposure of dexlansoprazole when used concomitantly with strong inducers [see CLINICAL PHARMACOLOGY]. Intervention: St. John’s Wort, rifampin: Avoid concomitant use with DEXILANT. Ritonavir-containing products: See prescribing information. CYP2C19 or CYP3A4 Inhibitors Clinical Im...
Inhibitors Of Cytochrome P4503A4 The main route ofmetabolismof corticosteroids, including budesonide, a component of SYMBICORT, is via cytochrome P450 (CYP) isoenzyme 3A4 (CYP3A4). After oral administration of ketoconazole, a strong inhibitor of CYP3A4, the mean plasma concentration of orally admi...
Strong CYP3A4 Inhibitors† Table 2: COLCRYS Dose Adjustment for Coadministration with Protease Inhibitors Treatment of gout flares with COLCRYS is not recommended in patients receiving prophylactic dose of COLCRYS and CYP3A4 inhibitors. Dose Modification In Renal Impairment ...
Ospemifene is primarily metabolized by CYP3A4 and CYP2C9; CYP2C19 also contributes to its metabolism; avoid moderate-to-strong inhibitors of these isoenzymes as they may increase risk of adverse effects May initiate or increase occurrence of hot flashes in some women Pregnancy and Lactation Osp...
Risk ofsleep paralysis, hypnagogic/hypnopompic hallucinations, andcataplexy-like symptoms increases with increasing doses Not recommended for patients with severe hepatic impairment or those taking a strong CYP3A inhibitor Pregnancy and Lactation
Medications used to treat cancer (Boronic acid-based proteasome inhibitors)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider. Green tea might interact with some medications used to treat cancer (boronic acid-based proteasome inhibitors). This might decrease its...