Can cause fetal harm; advise patients of the potential risk to a fetus and to use effective nonhormonal contraception Drug interaction overview Tazemetostat is a CYP3A4 substrate and CYP3A4 inducer Strong and moderate CYP3A inhibitors Avoid coadministration ...
Clinical Impact: Decreased exposure of dexlansoprazole when used concomitantly with strong inducers [see CLINICAL PHARMACOLOGY]. Intervention: St. John’s Wort, rifampin: Avoid concomitant use with DEXILANT. Ritonavir-containing products: See prescribing information. CYP2C19 or CYP3A4 Inhibitors Clinical Im...
故意自伤可发生在任何精神疾病中,常见的还有故意自伤综合症以及Munchausen综合症。心理社会因素对前途的悲观是自杀的重要因素,也和故意自伤者密切相关。此外负性的社会事件也是关键的因素。有研究发现在比较故意自伤、抑郁发作以及精神分裂症首发者病前生活事件的数量和类型,测量3类疾病的相对危险性,经历生活事件后6个月...
RIC8A (Resistance to Inhibitors of Cholinesterase 8 Homolog A (C. elegans), MGC104517, MGC131931, MGC148073, MGC148074, RIC8, synembryn) (MaxLight 750) Details MCPH1 (microcephalin 1, BRIT1, FLJ12847, MCT) (APC) Details BIN3 (bridging integrator 3, MGC14978) (HRP) Details Hrk (Activ...
避免于强效或者中效CYP3A抑制剂同时给药,可考虑使用CYP3A抑制剂作用较小的替代药物2.轻度肝损伤患者推荐剂量为每天140mg,不建议中度或重度肝损伤患者服用3.伊布替尼可能会增加接受抗血小板或抗凝血治疗患者的出血风险,密切监测4.华法林或其他维生素K拮抗剂不应与伊布替尼合并使用,尽量避免服用补充剂,如鱼油和维生素E...
Strong CYP3A4 inhibitors Reduce valbenazine dose Coadministration increases exposure (Cmax and AUC) to valbenazine and its active metabolite compared with the use of valbenazine alone Strong CYP2D6 inhibitors Consider reducing valbenazine dose based on tolerability ...
Inhibitors Of Cytochrome P450 3A4 Fluticasone propionate is a substrate of CYP3A4. The use of strong CYP3A4 inhibitors (e.g., ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir, ketoconazole, telithromycin) with FLOVENT HFA is not recommended because ...
Risk ofsleep paralysis, hypnagogic/hypnopompic hallucinations, andcataplexy-like symptoms increases with increasing doses Not recommended for patients with severe hepatic impairment or those taking a strong CYP3A inhibitor Pregnancy and Lactation
Some medications that are moved by these pumps include some chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole),proteaseinhibitors (amprenavir, indinavir, nelfinavir, saquinavir), H2 antagonists (cimetidine, ranitidine), some calcium cha...
Medications changed by the liver (Cytochrome P450 3A5 (CYP3A5) substrates)Interaction Rating:ModerateBe cautious with this combination.Talk with your health provider. Some medications are changed and broken down by the liver. Cannabidiol might decrease how quickly the liver breaks down some medications...