Substrates Inhibitors Inducers Often mentioned [2]: some Antidepressants Amitriptyline (tricyclic antidepressant) Imipramine (antidepressant) Clomipramine (tricyclic antidepressant) Clozapine (atypical antipsychotic) Caffeine (stimulant) Olanzapine (atypical antipsychotic) Ropivacaine (local anaesthetic) ...
Drug transporters 22 2. Tizanidine 22 2.1. Pharmacodynamics 23 2.2. Pharmacokinetics 24 2.3. Clinical use 25 2.4. Drug interactions 26 3. Caffeine 28 4. CYP1A2-inhibitors used in this study 28 4.1. Fluvoxamine 29 4.2. Ciprofloxacin 30 4.3. Oral contraceptives 30 4.3.1. Ethinylestradiol 31 ...
The objective of this study was to extend this method to drug interactions caused by CYP1A2 inhibitors and inducers. Methods First, initial estimates of the model parameters were obtained using data from the literature. Then, an external validation of these initial estimates was performed by ...
This study suggests that concurrent use of tizanidine with CYP1A2 inhibitors may lead to serious health consequences associated with low blood pressure such as falls and fractures.doi:10.1007/s40264-022-01200-4Lorenzo Villa-Zapatagrid.259906.10000 0001 2162 9738Department of Pharmacy Practice, College...
DRUG interactionsDRUG side effectsITRACONAZOLEDrug Safety -doi:10.1007/s40264-022-01240-wNoguchi, YoshihiroLaboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu-shi, JapanSpringer International PublishingDrug Safety