既往研究表明,CYLD是NF-kB信号通路的重要负调控因子,此外CYLD还是一种肝脏保护基因,敲除小鼠肝脏CYLD可激活触发门静脉周围肝细胞死亡,肝星状细胞和库普弗细胞活化,促进进行性纤维化、炎症、肿瘤坏死因子 (TNF) 的产生[8-10]。因此我们推测...
NF-κBCYLD氯化钆目的:观察氯化钆( GdCl3)预处理对性坏死性胰腺炎(ANP)大鼠肺泡巨噬细胞(AMs)肿瘤抑制因子CYLD及NF-κB的影响,探讨CYLD在ANP肺损伤中所起的作用.方法:36只SD大鼠随机分成正常对照组,ANP组,GdCl3预处理组.采用5%牛磺胆酸钠逆行性胰胆管注射制备ANP动物模型,GdCl3预处理组在造模前30 min经尾静脉...
近来研究发现CYLD基因编码一种K63特异性去泛素化酶,通过作用于核因子用(nuclearfactor^B,NF-kB)通路中的TRAF2、NEMO等位点抑制NF-用通路活化,同时亦参与调节JNK、Hedgehog等信号通路,发挥抗肿瘤效应。本文回顾并总结了CYLD基因发挥抗肿瘤效应的具体分子机制,讨论7CYLD基因突变在其所致皮肤附属器肿瘤表型发展中的意义...
Trompouki E , Hatzivassiliou E , Tsichritzis T , Farmer H , Ashworth A , Mosialos G ( 2003 ) CYLD is a deubiquitinating enzyme that negatively regulates NF-kB activation by TNFR family members . Nature 424 : 793 – 796Trompouki E , Hatzivassiliou E , Tsichritzis T , Farmer H ,...
Loss of function in CYLD may allow trichoepitheliomas and other neoplasms to develop by reciprocal induction of NF-KB pathways, which protect against TNF-alpha-mediated apoptosis. Associations: Presentation with multiple trichoepitheliomas is associated with multiple familial trichoepithelioma and Brooke–...
(CYLD), has a predominant role in the regulation of NF-κB, a transcription factor that promotes cell survival and oncogenesis. NF-κB activation involves attachment of K63-linked ubiquitin chains to its upstream signaling factors, which is thought to facilitate protein–protein interactions in ...
族 性圆柱瘤病 患者 的恢复生长控 制作用l4J。NF KB 的激活可被水杨酸类药物及PGA1所抑制,二者均可 抑制IKK p,CYLD丢失所致 的凋亡阻滞也可被水杨 酸类药物解除。 CYLD基 因缺失能减弱精子细胞凋亡早期波动。 导致小 鼠体 内缺陷的精子形成 。睾丸细胞中CYLD ...
Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-κB homodimers from the cytoplasmic pool of p50–p105 and nuclear translocation EMBO J., 16 (1997), pp. 3609-3620 View in ScopusGoogle Scholar Weissman, 2001 A.M. Weissman Themes and variations on ubiquitylatio...
联参与Fas信号诱导的细胞凋亡,在TNF一口信号途径中还可以介导NF—kB(nuclearfactor kappa—light—chain—enhancer ofactivatedB cells)信号的活化,从而促进细胞生长【61。但是 也有研究表明,RIPl蛋白通过基因位点变异无法进行泛素化后,更易与FADD、 caspase.8在胞浆内形成诱导细胞死亡的复合体II(Death—InducingSignaling...