In this study the putative structure of human cyclooxygenase-1 was constructed from ovine cyclooxygenase-1 by homology modeling, and the acetylsalicylic acid was docked into the arachidonic acid binding cavity of the enzyme. To characterize the shape of the potential energy surface of the acetylating...
Research Support, U.S. Gov't, P.H.S.; Review 关键词: Animals Humans Isoenzymes Prostaglandins Anti-Inflammatory Agents, Non-Steroidal Membrane Proteins Cyclooxygenase Inhibitors Protein Conformation Sequence Homology, Amino Acid Kinetics DOI: 10.1074/jbc.271.52.33157 被引量: 5367 年份: 1996 ...
(1993) Structural determination and promoter analysis of the chicken mitogen-inducible prostaglandin G/H synthase gene and genetic mapping of the murine homology. Arch Biochem Biophys 300:247–252 CrossRef Ristimaki A, Garfinkel S, Wessendorf J et al. (1994) Induction of cyclooxygenase-2 by ...
In the present study, primers designed to conserved regions of COX-2 were used for the homology cloning of sea bass (Dicentrarchus labrax) COX-2 gene and its regulation by different mitogen agents has been investigated.F. BuonocoreE. Randelli...