Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob disease. J Mol Neurosci 20: 25-30, 2003.Deininger, M. H., Bekure-Nemariam, K., Trautmann, K., Morgalla, M., Meyermann, R., and Schluesener, H. J. (2003). Cyclooxygenase-1 and −2 in ...
We have studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot the expression of COX-1 and -2 mRNA and protein in resting and activated peripheral blood or Jurkat T cells. Cells were activated by T cell receptor triggering with OKT3 antibodies and activation ...
Ziecik. Expression of cyclooxygenase-1 and -2 in the porcine endometrium during the estrous cycle and early pregnancy. Reprod Domest Anim 2006 . 41: 251 –– 257 . ,BLITEK, A., WACLAWIK, A., KACZMAREK, M.M., STADEJEK, T., PEJSAK, Z., ZIECIK, A.J.: Expression of ...
ATK was a potent inhibitor of COX-1 and COX-2 with IC(50) values of 0.5 and 0.1 microM in MC3T3-E1 cells and of 1.7 and 2.6 microM using the pure enzymes. Inhibition was reversible, with slow- and tight-binding characteristics. The arachidonyl carbon chain was essential, as the saturate...
The cyclooxygenases COX-1 and COX-2 metabolize arachidonic acid to prostaglandins (PGs) and thromboxanes and are thought to play a role in neuroinflammation and excitotoxicity, which are important components in the progression of neurodegenerative diseases. However, the exact role of each isoform in...
Localization of cyclooxygenase-1 and -2 in adult and fetal human kidney: implication for renal function. Am J Physiol Renal Physiol 272: F460-F468, 1997.Ko¨ mhoff M, Gro¨ ne HJ, Klein T, Seyberth HW, Nu¨ sing RM (1997) Localization of cyclooxygenase-1 and -2 in adult and fetal...
PGHS-1 and −2 are interesting in the context of both structural biology and enzymology in that they are homodimeric, heme-containing, glycosylated proteins with two catalytic sites. Moreover, the enzymes have a novel mechanism for membrane attachment; they are anchored to one leaflet of the ...
吲哚美辛是一种非选择性抑制剂环氧合酶 (COX) 1 和 2,参与从花生四烯酸前列腺素合成的酶 翻译结果4复制译文编辑译文朗读译文返回顶部 nonselectiveindomethacin是一个cyclooxygenase抑制剂(cox)1、2、酶的合成,参与名arachidonic酸 翻译结果5复制译文编辑译文朗读译文返回顶部 正在翻译,请等待... 相关内容 a大家好,...
Elevated levels of cyclooxygenase 1 and 2 in human cyclosporine induced gingival overgrowth. This study was carried out to immuno-localize and estimate the levels of cyclooxygenase 1 and 2 in human gingival tissue samples from healthy individuals, ... SR Rao,TM Balaji,PSG Prakash,... - 《Prost...
The inhibition of COX-1 was evaluated using intact bovine platelets as the enzyme source, whereas LPS-stimulated human monocytes served as the enzyme source for inducible COX-2. The determination of arachidonic metabolites was performed by HPLC for COX-1 and RIA for COX-2. The balance between ...