Virtually nothing is known about the details of the regulation of PGHS-1 gene expression. The PGHS-2 gene is 8 kilobase pairs in length and contains 10 exons (18). PGHS-2 expression can be induced through multiple signaling pathways involving protein kinases A and C, tyrosine kinases, ...
Contrary to COX-1, which is constitutively expressed, COX-2 expression is subject to regulation. For example, COX-2 levels are increased in inflammatory reactions. Many signalling pathways can regulate COX-2 expression, not least those involving receptors for COX products themselves. Analysis of ...
(2002) Interleukin- 1beta-induced cyclooxygenase-2 expression is mediated through activation of p42/44 and p38 MAPKS, and NF-kappaB pathways in canine ... CM Yang,CS Chien,LD Hsiao,... - 《Cellular Signalling》 被引量: 213发表: 2002年 Expression of cyclooxygenase 1 and 2 in the canine...
A series of 6,7-diaryl-2,3-1 H-dihydropyrrolizines was prepared as COX-1/COX-2 and 5-LOX inhibitors. The inhibition of COX-1 was evaluated using intact bovine platelets as the enzyme source, whereas LPS-stimulated human monocytes served as the enzyme source for inducible COX-2. The det...
aThe cyclooxygenase and lipoxygenase pathways that produce prostaglandins (PGs) and hydroxyeico-satetraenoic acids (HETEs) were studied in inflamed rabbit cornea. A cryogenic lesion was induced and five days later the epithelium, stroma and endothelium were isolated and incubated with [1-14c]...
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin have been shown to suppress transcription factor NF-κB, which controls the expression of genes such as cyclooxygenase (COX)-2 and cyclin D1, leading to inhibition of proliferation of tumor cells. There is no systematic study as to...
Nuclear factor-kappa B (NF-κB)-DNA-binding activity was determined by gel mobility shift assay.PRP extracts were found to inhibit the production of TNF-α, IL-1β, and PGE(2), reduce the expressions of COX-2 at the mRNA and protein levels induced by LPS, and reduced the production ...
New Pharmacotherapy for Airway Mucus Hypersecretion in Asthma and COPD: Targeting Intracellular Signaling Pathways. AbstractAirway mucus hypersecretion is a pathophysiological feature of asthma and chronic obstructive pulmonary disease (COPD). The hypersecretion is assoc... HY Lai,DF Rogers - 《Journal ...
cyclooxygenases-1 and -2. The former is regarded as a constitutive or housekeeping enzyme, while the latter is inducibly expressed. Both isoforms are similar to each other, and the sequence identity between them is about 70%. The enzyme is a so-called mosaic protein, which consists of three...
New targets aimed at cellular COX-2/PGE2 signalling pathways have provided therapeutic strat- egies for the treatment of NSCLC metastasis12,13. 1Department of Biotherapy, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210011, P.R. China. 2Cancer Center, Department of...