Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry. However,whereas its degradation by the proteasome in mid mitosis was thought to be essential for mitosis to proceed,recent...
The imbalance of cell cycle regulatory protein cyclinA2 and its inhibitor p21 expression in neonatal rats exposed to hyperoxia may be one of the related factors that interfere with the development of BPD alveoli. 【Key words】 cyclinA2; p21; Alveolar dysfunction; Hyperoxia; Neonatal rats Fund prog...
Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2. Oncogene. 29:6245-6256.Pan, J.; Nakade, K.; Huang, Y.C.; Zhu, Z.W.; Masuzaki, S.; Hasegawa, H.; Murata, T.; Yoshiki, A.; Yamaguchi, N.; Lee, C.H.; et al. ...
Cyclin A2 binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. Cyclin A2 could be phosphorylated during the G2/M. 实验方案 Product Specific Protocols WB protocol for Cyclin A2 antibody 82148-1-RR Download protocol IHC protocol for Cyclin ...
Cyclin A2 binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. Cyclin A2 could be phosphorylated during the G2/M. Protocols Product Specific Protocols WB protocol for Cyclin A2 antibody 18202-1-AP Download protocol IHC protocol for Cyclin ...
ConclusionThe imbalance of cell cycle regulatory protein cyclinA2 and its inhibitor p21 expression in neonatal rats exposed to hyperoxia may be one of the related factors that interfere with the development of BPD alveoli. KEYWORDS: cyclinA2;p21;Alveolar dysfunction;Hyperoxia;Neonatal rats Corresponding...
CCNA2 is a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins act as regulators of CDK kinases. Various cyclins demonstrate distinct expression and degradation patterns which contribute to the temp...
A2 is synthesized at the onset of S phase and localizes to the nucleus,where the cyclin A2-CDK2 complex is implicated in the initiation and progression of DNA synthesis.Phosphorylation of CDC6 and MCM4 by the cyclin A2-CDK2 complex prevents re-replication of DNA during the cell cycle. ...
JDP2 was recruited to the promoter of the gene for cyclin-A2 (ccna2) at the AP-1 site. Cells lacking Jdp2 had elevated levels of cyclin-A2 mRNA. Furthermore, reintroduction of JDP2 resulted in the repression of transcription of ccna2 and of cell-cycle progression. Thus, transcription of...
近日,陆军军医大学史春梦教授与中山大学孙逸仙纪念医院尹东研究员在Journal of Cell Biology发表研究论文Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle。该研究发现了Cyclin D1 mRNA...