occurs on nonconsensus sites Phosphorylation of p50 by PKG directly impacts its DNA binding characteristics The subcellular localization of NF-κB subunits is not affected by phosphorylation with PKG Discussion Acknowledgements References The transcription factor NF-κB is activated in cellular stress ...
Using isolated, permeabilized cilia, we find, independent of [Ca ++ ], that cAMP -dependent protein phosphorylation in L-cilia occurs uniquely and reversibly on three low molecular weight polypeptides of 23,000, 18,000, and 14,000 daltons. Phosphorylation is maximal at cAMP concentrations above ...
Alongside this phosphorylation, the dynamic co-assembly of larger KaiABC complexes plays a controlling role in this circadian system (8). This relatively simple circadian pacemaker provides such a robust system that it can even be reproduced in vitro, requiring only the three Kai proteins and the...
The regulation of mammalian carbohydrate metabolism occurs by hormonal and non-hormonal mechanisms; the hormonal mechanisms may be cyclic AMP-dependent or cyclic AMP-independent. The regulation may be rapid involving covalent modification (usually phosphorylation) of enzymes or alterations in the concentrati...
While activation of NMDA receptors lead to the phosphorylation of CREB at Ser133 in young neurons in culture (West et al., 2001), more recent evidence suggests that sustained CREB occurs in older neurons through neuronal activity via NMDA receptor activation (Lee et al., ...
Synthesis of chymoelastase and trypsin by the entomopathogenic fungus Metarhizium anisopliae occurs rapidly (<2 h) during carbon and nitrogen derepression... RJS Leger,PK Durrands,RM Cooper,... - 《Archives of Microbiology》 被引量: 192发表: 1988年 Centrosome phosphorylation and the developmental ...
J. Interplay of palmitoylation and phosphorylation in the trafficking and localization of phosphodiesterase 10A: implications for the treatment of schizophrenia. J. Neurosci. 30, 9027–9037 (2010). This study presents a key finding showing that two PTMs can compete to regulate the subcellular ...
in the protein but may also be of the threonine or serine amino acid. The protein may be any protein inside the target cell that can be phosphorylated. Typically the protein in which phosphorylation occurs is constitutively phosphorylated to some extent and the level of its phosphorylation is ...
Thus, the higher production of ROS, which occurs concurrently with the higher expression of VEGF-B, confirms the relationship between angiogenesis and oxidative stress. Exercise induces muscle tissue calcineurin signaling pathways to enable muscle tissue contraction. It has been shown in the literature ...
cyclic AMP-independent phosphorylation activity. Cyclic AMP in some way inhibits the expression of certain genes, whereas it increases the expression of others. We have identified those gene products which are increased, those which are decreased, and those which remain unaltered during cyclic AMP-...