这些发现强烈表明靶向 CXCR4/CXCL12 轴可能是抑制血管生成的潜在治疗靶点。 Figure 7.Receptor-ligand interaction analysis reveals the CXCR4/CXCL12 axis as a therapeutic target. 八、靶向 CXCR4/CXCL12 轴抑制血管生成的体外和体内验证...
However, research in recent years has proved that the CXC chemokine receptor type 4 (CXCR4)/CXC motif chemokine ligand 12 (CXCL12) axis plays a critical role in the upstream of the inflammatory pathway due to its chemotaxis to inflammatory cells. Blocking the chemotaxis of inflammatory cells by...
1. Mollica Poeta V, et al. Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy. Front. Immunol. 2019. doi: 10.3389/fimmu.2019.00379 2. Zhou, et al. Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy. Curr Med Chem. 2019. doi:10.2174/0929867324666170830111531.3. Bianch...
CXCR4是一种7跨膜G蛋白偶联受体（GPCR），G蛋白位于细胞膜的内侧，由三个不同的亚基组成，即α、β和γ。在与CXCL12相互作用时，CXCR4触发异源三聚体G蛋白解离为Gα和Gβγ亚基，并转化与G结合的鸟苷二磷酸蛋白质转化为三磷酸鸟苷，然后激活下游信号传导（图1）。正常情况下，CXCR4在发育、稳态和炎症过程中调...
1.Yaru Yang,Jiayan Li,Wangrui Lei,Haiying Wang,Yunfeng Ni,Yanqing Liu,Huanle Yan,Yifan Tian,Zheng Wang,Zhi Yang,Shulin Yang,Yang Yang,and Qiang Wang,CXCL12-CXCR4/CXCR7 Axis in Cancer:from Mechanisms to Clinical Applications,Int.J.Biol.Sci.2023...
[11] Chen, Guanget al. "Inhibition of chemokine (CXC motif) ligand 12/chemokine (CXC motif) receptor 4 axis (CXCL12/CXCR4)-mediated cell migration by targeting mammalian target of rapamycin (mTOR) pathway in human gastric carcinoma cells." The Journal of biological chemistry vol. 287,15 (...
WHIM综合征是一种罕见的遗传性联合免疫缺陷病,由CXCR4/CXCL12通路的过度信号传导导致骨髓白细胞动员和运输减少引起。若马伏沙福获批,将有可能成为WHIM综合征患者的首个疗法。 巴沙福肽 巴沙福肽是Spexis AG(原Polyphor AG)研发的一款强效、高选择性双环肽类CXCR4拮抗剂。
1.Yaru Yang,Jiayan Li,Wangrui Lei,Haiying Wang,Yunfeng Ni,Yanqing Liu,Huanle Yan,Yifan Tian,Zheng Wang,Zhi Yang,Shulin Yang,Yang Yang,and Qiang Wang,CXCL12-CXCR4/CXCR7 Axis in Cancer:from Mechanisms to Clinical Applications,Int.J.Biol.Sci.2023,Vol.19 ...
在肿瘤研究中,发现趋化因子CXCL12及受体CXCR4在肿瘤增殖、侵袭、转移、新血管形成等多个过程中发挥重要作用,本文对CXCL12/CXCR4轴与卵巢肿瘤的关系作一综述。 标签:CXCL12/CXCR4;卵巢肿瘤;转移; 侵袭、转移是卵巢恶性肿瘤最主要的生物学特性,亦是导致卵巢恶性肿瘤患者发病和死亡的重要原因。卵巢恶性肿瘤转移有四种途径...
特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种病因未明的肺间质性疾病,以肺泡上皮损伤、纤维细胞增殖、肌成纤维细胞形成、细胞外基质沉积为主要病理特征。CXCR4是纤维细胞主要的趋化因子受体,CXCL12是CXCR4的唯一配体。大量研究表明,在缺氧、HIF-1α、PI3K