even though CXCR4-VN or CXCR4-VC was expressed adequately and colocalized with μOR at the cell surface. This observation is consistent with a previous report indicating the lack of physical interaction between
The data represent means plus or minus SEM (n = 2). We thus evaluated the effect of βarr2 expression on migration of CXCR4wt- or CXCR41013-expressing HEK cells toward CXCL12. Cells were transfected with βarr2-GFP or the pN1-eGFP vector, and CXCL12-induced migration of cells with ...
Cancer trap CXCL12/CXCR4 1. Introduction Metastasis, responsible of >90 % of death for cancer [1,2], derives from a multistep, inefficient process in which primary tumor shapes distant organ microenvironment permissive to metastatic outgrowth [3,4]. In April 2024, the search of ‘Circulating ...
We provide further evidence that disruption of CXCL12/CXCR4 signaling in the bone marrow is a key step in HPC mobilization. G-CSF regulates CXCL12 expression in the bone marrow primarily at the mRNA level. Evidence is provided that G-CSF inhibits osteoblast number and activity through an ...
Data are expressed as mean plus or minus SEM. Student t test was applied for statistical analysis. Results Homodimerization and heterodimerization of CXCR7 We have characterized the relative propensities of CXCR7 and CXCR4 to homodimerize and heterodimerize using a BRET-based titration assay.18,27...
Data are expressed as mean plus or minus SEM. Student t test was applied for statistical analysis. Results Homodimerization and heterodimerization of CXCR7 We have characterized the relative propensities of CXCR7 and CXCR4 to homodimerize and heterodimerize using a BRET-based titration assay.18,27...