CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. J Hepatol 2012;57:1044-1051.Oo, Y. H., V. Banz, D. Kavanagh, E. Liaskou, D. R. Withers, E. Humphreys, G. M. Reynolds, L. Lee-Turner, N. Kalia, S. G. Hubscher, et al. 2012....
CXCR3/CCR6 double positive germinal center T follicular helper cells (GC TFH) harbor residual virus during cART initiated during hyperacute HIV infectiondoi:10.1016/S2055-6640(20)30634-8Z. NdhlovuO. BaiyegunhiT. Ndung'uB.D. WalkerJournal of Virus Eradication...
We therefore hypothesized that simultaneous targeting of both CXCR3 and CCR6 with a bispecific antibody (BsAb) might result in decreased chemotaxis and/or specific depletion of pro-inflammatory T cell subsets. In this study, we designed and characterized a fully humanized BsAb. We show that the ...
其次,Th17细胞表面CXCR3、CCR6、CCR4表达量和Glo之间存在负相关性,和Alb、TBIL、ALT、PCⅢ、IVc、LN、HA之间存在正相关性,提示Thl7细胞表面趋化因子受体表达量增加会对慢性乙肝患者病情进展产生直接影响,炎症相关趋化因子增加会进一步提高趋化因子受体表达量,最终形成一种恶性循环。
雷公藤多苷含药血清对变应性接触性皮炎小鼠淋巴细胞表面CXCR3、CCR3表达的影响 维普资讯 http://www.cqvip.com
Characterization of circulating dendritic cells in melanoma: role of CCR6 in plasmacytoid dendritic cell recruitment to the tumor. Dendritic cells (DCs) are central cells in the development of antitumor immune responses, but the number and function of these cells can be altered in vari... J Char...
15. Based on CXCR3 and CCR6 expression, cTfh cells can be divided into three major subsets: Th1-like cTfh (Tfh1: CXCR3+CCR6−) cells, Th2-like cTfh (Tfh2: CXCR3−CCR6−) cells and Th17-like cTfh (Tfh17: CXCR3−CCR6+) cells15,16. According to PD-1, ICOS and CCR7...
This could perpetuate an amplification loop for CXCR3-driven Th1 and effector CD8 + T cells recruitment to the gut, while impairing Th17 cells homing through the CCR6-CCL20 axis in treated HIV-1–infected individuals. 展开 关键词: HIV-1 gut CXCR3 Th1 CD8 IFN-γ IL-18 CCL20 CCL25 ...
Thl7细胞 表面高表达IL.23R、CCR6、CCR4等,RORm是其特征性的转录因子。许多研究 表明这些不同的T细胞亚群不是分化定型细胞,它们具有一定的可塑性,通过分 泌细胞因子相互影响、相互制约,形成网络维持动态平衡,一旦失衡就可能发生 免疫功能失常,导致疾病发生。 趋化因子(chemokin)是一组具有趋化作用的细胞因子,除趋化...
Neutrophils do not express CXCR3 and migrate to target tissues by using other chemokine receptors such as CXCR1, CXCR2, CXCR4, and CCR1 [30]. Lack of CXCR3 would therefore not be expected to affect neutrophil migration and in this GVHD model its expression appears to be critical only for...