CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver. J Hepatol 2012;57:1044e51.Oo YH, Banz V, Kavanagh D, Liaskou E, Withers DR, Humphreys E, Reynolds GM, Lee-Turner L, Kalia N, Hubscher SG, Klenerman P, Eksteen B, Adams DH. CXCR3-...
CXCR3/CCR6 double positive germinal center T follicular helper cells (GC TFH) harbor residual virus during cART initiated during hyperacute HIV infectiondoi:10.1016/S2055-6640(20)30634-8Z. NdhlovuO. BaiyegunhiT. Ndung'uB.D. WalkerJournal of Virus Eradication...
其次,Th17细胞表面CXCR3、CCR6、CCR4表达量和Glo之间存在负相关性,和Alb、TBIL、ALT、PCⅢ、IVc、LN、HA之间存在正相关性,提示Thl7细胞表面趋化因子受体表达量增加会对慢性乙肝患者病情进展产生直接影响,炎症相关趋化因子增加会进一步提高趋化因子受体表达量,最终形成一种恶性循环。
CCR4(+)CCR6(-) T cells expressed CXCR4 but not CCR5 and were permissive to X4 HIV only. CXCR3(+)CCR6(-) T cells expressed CCR5 and CXCR4 but were relatively resistant to R5 and X4 HIV in vitro. Total CCR6(+) T cells compared with CCR6(-) T cells harbored higher levels of ...
结论:根据肿瘤细胞是否表达CXCR3或CCR3来进一步分类T—NHL.还需进一步的实验验证。关键词淋巴瘤,非霍奇金;CXCR3;CCR3;免疫组织化学T细胞非霍奇金淋巴瘤(T—NHL)是一群高度异质性的恶性淋巴瘤,其诊断、分类及分子发病机制的研究一直是肿瘤病理学中最为困难和最有争议的领域之一。2001年WHO关于淋巴及造血系统肿瘤...
CXCR5+CD4+T细胞亚群与重症肌无力的相关性研究 目的:研究外周血CXCR5+CD4+T细胞三个亚群(CXCR3+CCR6-Th1样,CXCR3-CCR6-Th2样,CXCR3-CCR6+Th17样)与重症肌无力(MG)的相关性.探讨MG的发病机制,为MG的治疗提供新思路. ... 赵敏 - 《中南大学》 被引量: 2发表: 2014年 不同病期慢性阻塞性肺疾病趋化因子...
15. Based on CXCR3 and CCR6 expression, cTfh cells can be divided into three major subsets: Th1-like cTfh (Tfh1: CXCR3+CCR6−) cells, Th2-like cTfh (Tfh2: CXCR3−CCR6−) cells and Th17-like cTfh (Tfh17: CXCR3−CCR6+) cells15,16. According to PD-1, ICOS and CCR7...
At a molecular level, pro-metastatic macrophages have been characterized as uniquely expressing VEGFR1, CCR2, and CX3CR1, while lacking surface CXCR4 expression3,9, suggesting that these cells are distinct from proangiogenic macrophages6. Kitamura et al. have demonstrated that CCR1 and CCR2 ...
CCL20/CCR6及CXCL10/CXCR3在胃癌组织中的表达及意义 目的 胃癌是最常见的消化道恶性肿瘤之一,趋化因子及其受体在胃癌的发生,发展中所起到的作用也越来越受到人们的关注. 趋化因子是细胞因子家族中的一类分泌型小分子蛋白... 王涛 - 泰山医学院 被引量: 0发表: 0年 CXCL10、CXCR3及T细胞亚群在进展期白癜风患...
Neutrophils do not express CXCR3 and migrate to target tissues by using other chemokine receptors such as CXCR1, CXCR2, CXCR4, and CCR1 [30]. Lack of CXCR3 would therefore not be expected to affect neutrophil migration and in this GVHD model its expression appears to be critical only for...