他们的最新研究“CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers”已于著名期刊《Science》上发表。作者发现,由 CXCL9 和 SPP1 这两个基因的表达所定义的巨噬细胞极性的变化是肿瘤微环境的一个简单而关键的特征。CXCL9:SPP1的比例可以描述癌症中抗肿瘤免疫细...
近期,来自瑞士University of Geneva的Mikael J. Pittet研究组在Science上发表题为CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers的文章,将病人个体差异这一变量加入RNA测序数据处理和分析之中,并进一...
近期,来自瑞士University of Geneva的Mikael J. Pittet研究组在Science上发表题为CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers的文章,将病人个体差异这一变量加入RNA测序数据处理和分析之中,并进一步确定了人类肿瘤发展和预后的新指标。 首先,作者收集了来自51位...
2023年8月4日,瑞士日内瓦大学领导的国际研究团队在Science(IF=56.9)发表了研究论文:CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers。 由 CXCL9 和 SP…
内容提示: CANCER IMMUNOLOGYCXCL9:SPP1 macrophage polarity identifies a networkof cellular programs that control human cancersRuben Bill 1,2,3,4,5 †, Pratyaksha Wirapati 1,2,3 †, Marius Messemaker 4,6 , Whijae Roh 7 , Beatrice Zitti 1,2,3 ,Florent Duval 1,2,3 , Máté Kiss 1...
研究发表在《Science》上，文章标题为：“CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers”。研究人员利用患者间差异，研究肿瘤微环境如何影响头颈部鳞状细胞癌的进展。作者发现，由两个基因CXCL9和SPP1的表达决定的巨噬细胞极性的变化是肿瘤微环境的一个简单但...
CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers CXCL9:SPP1巨噬细胞极性识别控制人类癌症的细胞程序网络 相关领域 极性(国际关系)巨噬细胞肿瘤微环境癌症生物癌症研究细胞医学肿瘤细胞内科学遗传学体外
Deciphering tumor microenvironment: CXCL9 and SPP1 as crucial determinants of tumor-associated macrophage polarity and prognostic indicatorsTUMOR microenvironmentCANCER invasivenessMACROPHAGESCELL anatomyCLINICAL medicineThe tumor microenvironment (TME) is an intricate system comprised of tumor cells and the ...
Inhibition of macrophage infiltration has been shown to reduce the development of hepatic inflammation and AS, highlighting it as one of the common mechanisms linking AS and NASH51,52. Copper is an essential trace element involved in oxidative stress and energy metabolism. It has been found that ...
Macrophage infiltration plays a central role in AS and was previously thought to be a late consequence of steatosis. However, recent studies have shown that the activation and infiltration of macrophages are also early initiating event in NASH. Inhibition of macrophage infiltration has been shown to...