ACS Chem. Biol. | 使用化学合成的四功能探针鉴定CXCL14的受体蛋白 大家好,本周分享一篇发表在ACS chem bio上的文章,文章题目为“Identification of Low-Density Lipoprotein Receptor-Related Protein 1 as a CXCL14 Receptor Using ...
In order to further explore its mechanism, CXCR4 and CXCR7 were suggested as receptors by Membrane-Anchored Ligand and Receptor Yeast Two-Hybrid technology. Through metabolomic techniques, we inferred that CXCL14 promotes the development of neurons by regulating fatty acid anabolism and...
cell lines of CXCL14, they hypothesized that potential receptors include ACKR2, CXCR4, GPR25, or GPR182. Experimental validation showed that only ACKR2 could induce the downstream pathways of CXCL14, but ACKR2 is not a direct receptor for CXCL14 [39]. It is true that receptor expression...
ReliaTech全称为受体配体技术有限公司 (Receptor Ligand Technologies GmbH),1999年成立,总部位于德国不伦瑞克,是一家后基因组生物技术公司。ReliaTech主要专注于受体和配体的发现与研究。此外,ReliaTech也开发应用于血管与淋巴管生成研究的相关高品质试剂。目前ReliaTech提供近2800款产品,产品线主要包括重组蛋白(细胞因子、生...
intracellular reactive oxygen species induce CXCL14 upregulation in breast cancer cells, leading to accumulation in the endoplasmic reticulum (ER). Under these circumstances, CXCL14 directly interacts with the inositol 1,4,5-trisphosphate (IP3) receptor in the ER to induce calcium release into the...
However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 α ...
CD206蛋白——ACROBiosystems百普赛斯 价格: 价格电议 产品详情: CD206产品信息英文名称:Macrophage mannose receptor 1 中文名称:巨噬细胞甘露糖受体-1 靶点别称:MMR,... 纯度:95% 包装规格:100ug 用途:生物制药 货号:CD206 品牌:ACRO 产地:北京 蛋白相关产品报价 更多> 产品标题 价格 产地 公司名称 更新日...
Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unkno...
which represents a tumor-supportive role. Further analysis of this theory has clarified that CXCL14 introducing into glioma cell lines (U87MG and LN229 cells) leads to the phosphorylation of ERK1/2 and, subsequently, tumor cell proliferation. In this respect,GPR85likely the CXCL14 receptor[49...
Although CXCL14 receptors have not yet been identified, the intracellular activity of CXCL14 in breast cancer cells suggests that the CXCL14 receptor(s) and signal transduction pathway(s) may be different from those of conventional CXC-type chemokines. Recombinant rat CXCL14 contains 77 amino ...