在机制上,小鼠乳腺BCs表达的FGD5抑制了活化转录因子3 (ATF3)的转录活性,导致随后的转录激活和CXCL14的分泌。此外,在原代小鼠乳腺间质内皮细胞中,CXCL14/CXCR4/ERK信号的激活可增强HIF-1α调控的hedgehog配体的表达,从而启动一个正反...
CXCL12的受体CXCR4是第一个被鉴定出与CXCL14有直接相互作用的受体[22]。先前的研究表明，CXCL14可能作为CXCR4的诱饵配体起作用，并抑制CXCL12激活CXCR4信号传导[23]。相反的是，另外一项研究提出CXCL14在CXCL12的存在下协同激活CXCR4。尽管存在高亲和力相互作用，但CXCL14 主要是协同CXCL12激活CXCR4 信号转导[24]...
CXCL14 had no effect on CXCL12-induced CXCR4 phosphorylation at serines 346,347. • CXCL12-induced dynamic mass redistribution was not changed by CXCL14. • G protein and Erk1,2 signaling of CXCR4 were also unaffected. • CXCL12 should still be considered the only relevant chemokine li...
CXCL14 also exerts an inhibitory effect on the CXCL12/CXCR4 signaling pathway, which is involved in the maintenance of T‐helper (Th)2 bias, and promotes Th1 immune response under the physiological and pathological conditions. CXCL14 has been shown to be a highly selective chemoattractant for ...
CXCL12 and CXCL14 are evolutionarily conserved members of the CXC-type chemokine family. CXCL12 binds specifically to the G-protein-coupled receptor CXCR4 to induce the migration of primordial germ cells, hematopoietic stem cells, and inflammation-associ
www.nature.com/scientificreports OPEN Global Gene Expression Analysis in an in vitro Fibroblast Model of Idiopathic Pulmonary Fibrosis Received: 25 August 2017 Accepted: 13 February 2018 Published: xx xx xxxx Reveals Potential Role for CXCL14/ CXCR4 Luis R. Rodriguez 1, Margaret Emblom-...
DOI 10.1515/bmc-2014-0007 BioMol Concepts 2014; 5(2): 167–173 Short Conceptual Overview Takahiko Hara* and Kosuke Tanegashima CXCL14 antagonizes the CXCL12-CXCR4 signaling axis Abstract: CXCL12 and CXCL14 are evolutionarily con- served members of the CXC-type chemokine ...
CXCL14CXCR4reactive oxygen speciesasthmaCXCL14 (C-X-C motif chemokine ligand 14) is expressed in the airway epithelial cells of patients with asthma. However, the mechanisms of CXCL14 secretion and its effects on asthma pathogenesis remain unclear. Here, we investigated the role o...
(STRING), suggesting that CXCR4, CXCL12, CXCR3, CXCR2, CCR2, CCR1, CXCR5, CCR7, CXCR1, and CCR5 may have close interactions with CXCL14 and could be potential receptors [34]. However, this conclusion does not hold in pan-cancer studies. In one breast cancer study, the authors ...
One group proposed that Cxcl14 is a ligand for chemokine (C-X-C motif) receptor 4 (CXCR4) and functions as an antagonist for the cognate ligand of CXCR4, chemokine (C-X-C motif) ligand 12 (Cxcl12),30 although another study demonstrated that Cxcl14 does not directly modulate CXCR4 ...