The chemokine CXCL12/SDF-1 has diverse capability to influence leukocyte migration, tumor metastasis, and hematopoiesis, with signaling pathways previously described through a G-protein coupled receptor (CXCR4) and an atypical chemokine receptor (ACKR3). Here we show ...
通过其受体CXCR4和ACKR3刺激单核细胞和T淋巴细胞的迁移,并减少单核细胞对ICAM-1(β-2整合素的配体)表面的粘附。SDF1A/CXCR4信号轴通过LYN激酶抑制β-2整合素LFA-1介导的单核细胞与ICAM-1的粘附。抑制由T细胞系适应的HIV-1介导的CXCR4感染。在心肌梗死后起保护作用。诱导各种细胞中表达的ACKR3的下调和内化。在...
cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular ...
It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Cxcl12 has several critical functions during embryonic development such as B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation....
17、,ACKR3的编码蛋白)不结合G蛋白也不调节细胞迁徙,充当CXCL12和CXCL11的清道夫,干扰影响肿瘤干细胞归巢的CXCL12/CXCR4轴,在皮下淋巴瘤动物模型中,ACKR3的功能性表达是弥漫性大壁细胞瘤定植引流淋巴结所必须的。另外,在广泛转移的淋巴瘤动物模型中,ACKR3的功能性表达也是骨髓、脑侵袭以及原位肿瘤生长所必须的。提...
beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. It also plays a protective role after myocardial infarction, induces down-regulation and internalization of ACKR3 expressed in various cells and stimulates the ...
也与型趋化因子受体ACKR3结合,它激活β -抑制素通路,并作为SDF-1的清除受体。与整合素的变构位点(site 2)结合,以不依赖cxcr4的方式激活整合素ITGAV:ITGB3、ITGA4:ITGB1和ITGA5:ITGB1。通过LYN激酶作为单核细胞迁移的正调控因子和单核细胞粘附的负调控因子。刺激单核细胞和t淋巴细胞通过其受体CXCR4和ACKR3的...
et al. ACKR3 regulation of neuronal migration requires ACKR3 phosphorylation, but not β-arrestin. Cell Rep. 26, 1473–1488.e9 (2019). Article PubMed CAS Google Scholar Wang, Y. et al. CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Neuron 69, 61–76 (2011...
role in acting as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand...
Cardiac development is also affected by ACKR3, which demonstrates that the CXCL12/CXCR4/ACKR3 system is important in cardiogenesis.Leukocyte-derived seven-transmembrane domain receptor (LESTR) was shown to be a co-factor for human immunodeficiency virus (HIV)-1 cell entry. CXCL12 has been shown...