The chemokine CXCL12/SDF-1 has diverse capability to influence leukocyte migration, tumor metastasis, and hematopoiesis, with signaling pathways previously described through a G-protein coupled receptor (CXCR4) and an atypical chemokine receptor (ACKR3). Here we show ...
Cxcl12 plays an important role in acting as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated...
cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular ...
and heart ventricular septum formation. Cxcl12 plays an important role in acting as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. It stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and ...
也与型趋化因子受体ACKR3结合,它激活β -抑制素通路,并作为SDF-1的清除受体。与整合素的变构位点(site 2)结合,以不依赖cxcr4的方式激活整合素ITGAV:ITGB3、ITGA4:ITGB1和ITGA5:ITGB1。通过LYN激酶作为单核细胞迁移的正调控因子和单核细胞粘附的负调控因子。刺激单核细胞和t淋巴细胞通过其受体CXCR4和ACKR3的...
Because of this unique function, CXCR7 was recently designated ACKR3 (atypical chemokine receptor 3) (15). Interaction of CXCL12 with CXCR4 modulates the migration of primordial germ cells and neural progenitors in developing embryos, the bone marrow homing of hematopoietic stem cells, and the ...
Secondly, in our study, we did not determine the concentrations and utility of CXCR7 (ACKR3), the atypical receptor for CXCL12, thereby not fully evaluating the overall ligand-receptor axis Cancer Management and Research 2023:15 Powered by TCPDF (www.tcpdf.org) https://doi.org/10.2147/CMAR....
17、,ACKR3的编码蛋白)不结合G蛋白也不调节细胞迁徙,充当CXCL12和CXCL11的清道夫,干扰影响肿瘤干细胞归巢的CXCL12/CXCR4轴,在皮下淋巴瘤动物模型中,ACKR3的功能性表达是弥漫性大壁细胞瘤定植引流淋巴结所必须的。另外,在广泛转移的淋巴瘤动物模型中,ACKR3的功能性表达也是骨髓、脑侵袭以及原位肿瘤生长所必须的。提...
The role of the CXCL12/CXCR4/ACKR3 axis in autoimmune diseases Front Endocrinol, 10 (2019) Google Scholar [29] C. Wang, W. Chen, J. Shen CXCR7 targeting and its major disease relevance Front Pharmacol, 9 (2018), p. 641 View PDFView articleGoogle Scholar [30] S.M. Rankin Chemokines...
CXCL12 exists in six splice variants in humans and interacts with the receptors CXCR4 and ACKR3, as well as by binding to glycosaminoglycans in tissues and on the endothelium. The gene that encodes CXCL12 is located on chromosome 10q11, unlike most other CXC chemokines. CXCL12 is one of the...