为了理解清楚CX3CR1+DCs对胸腺中微生物群特异性T细胞扩增的影响,我们使用了一种在CX3CR1启动子下表达白喉毒素受体的转基因小鼠(以下简称CX3CR1-DTR小鼠),这种小鼠在白喉毒素处理后,其体内CX3CR1+的细胞会被全部剔除。使用白喉毒素处理CX3CR1-DTR幼鼠组和其对应的幼鼠对照组,在小鼠断奶时给它们种植SFB。2周后...
Next, LLC cells were injected subcutaneously into CX3CR1DTR/+ mice, sensitive to diphtheria toxin (DT), and WT mice. After injection, tumors were irradiated with 8 Gy, and mice were treated with DT, leading to conditional ablation of CX3CR1-expressing cells. After three weeks, CX3CR1-...
Next, LLC cells were injected subcutaneously into CX3CR1DTR/+ mice, sensitive to diphtheria toxin (DT), and WT mice. After injection, tumors were irradiated with 8 Gy, and mice were treated with DT, leading to conditional ablation of CX3CR1-expressing cells. After three weeks, CX3CR1-...
DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur. J. Immunol. 38, 2776–2783 (2008). 34. Dahan, S. et al. EspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that ...
Elimination of CX3CR1 mononuclear phagocytes during the first 2 weeks after meningitis in CX3CR1-DTR transgenic mice did not protect mice from any of the systemic or hearing sequelae of pneumococcal meningitis.ConclusionsPneumococcal meningitis can have devastating effects on cochlear structure and ...
biomedicines Article Anti-Inflammatory Effects of Allocryptopine via the Target on the CX3CL1–CX3CR1 axis/GNB5/AKT/NF-κB/Apoptosis in Dextran Sulfate-Induced Mice Yang Yang 1,† , Tingyu Ding 1,2,†, Gang Xiao 1, Jialu Huang 3, Dan Luo 1, Meishan Yue 3, Yue Su 3, Sujuan...