the macrophage/dendritic cell (DC) lineage. However, the relationship o the CSF-1R + CX 3 CR1 + macrophage/DC precursor (MDP) with other DC precursors and the role o CX 3 CR1 in macrophage and DC development remain unclear. We show that MDPs give rise to con- ...
此外,目前尚不清楚tau蛋白病理学和大脑内局部炎症反应在多大程度上影响更广泛的免疫系统。为了解决这些问题,作者对MAPT (编码tau的基因)致病性变异携带者(n=8)和健康非携带者(n=8)的外周血单核细胞(PBMCs)进行了单细胞RNA测序(scRNA-s...
趋化因子及其受体调控细胞的定向迁移,在炎症反应、细胞和器官的发育、肿瘤的发生发展及转移等方面发挥关键作用。趋化因子根据其N端半胱氨酸数量和分布的差异可分为CC、CXC、CX3C和XC四个亚家族。不同亚家族内的趋化因子与受体间的互相...
哎,说到这个cx3cr1蛋白,真是个让人着迷的小家伙。它在细胞间通讯中扮演着重要角色,就像个细胞界的社交达人。你知道吗?这个蛋白的结构可不简单,它得精确地折叠成特定的形状,才能和它的伙伴们——那些化学信号分子——正确地互动。 首先,得说说这个蛋白的氨基酸链。它就像一串长长的珍珠项链,每一颗珍珠都是一个...
However, MACs showed significantly higher CX3CR1 expression levels than did DC. We also observed an antagonistic CX3CR1 regulation by interferon (IFN)-γ and interleukin (IL)-4 during MAC activation through the classical and alternative MAC pathways, respectively. IFN-γ inhibited the loss of ...
趋化因子受体CX3CR1的分子结构及生物学功能 维普资讯 http://www.cqvip.com
CX3CR1主要表达在单核细胞、巨噬细胞、DC细胞、T细 胞、NK细胞、小胶质细胞等。根据趋化受体与趋化因子结合部位不同,将其分为4类:CX3CR1、 CXCR1‑CXCR5、XCR1、CCR1‑CCR9。在外周血中,CX3CR1多位于单核细胞和白细胞的细胞膜上, 既参与细胞的趋化作用,也与细胞的粘附作用有关。炎症细胞从外周循环...
Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chem...
摘要: Dendritic cells (DC) represent a rather heterogeneous cell population with regard to morphology, phenotype, and function and, like most cells of the immune system, are subjected to a continuous renewal process. CD103关键词:integrin alphaE Bone Marrow green fluorescent protein 骨髓 ...
DCUN1D4蛋白抗体,英文名称:Anti-DCUN1D4,保存条件:保存在4℃(短期)或-20℃(长期),形态:Liquid,亚型:IgG等,应用范围:ELISA,WB,IHC,IP,FC,IF等,规格:100ul///200ul,宿主:Rabbit or Mouse等,适用物种:Human,Mouse,Rat等 磷酸化组蛋白去乙酰化酶7抗体,英文名称:Anti-phospho-HDAC7 (Ser318),保存条件:保...