Cx3cr1-GFP小鼠是一种在Cx3cr1基因座插入绿色荧光蛋白(GFP)基因的转基因小鼠模型。Cx3cr1(趋化因子受体3,与趋化因子CX3CL1配体结合)主要在单核细胞、巨噬细胞、微小胶质细胞和某些树突状细胞中表达。Cx3cr1-GFP小鼠主要用于研究这些细胞的分布、功能及其在免疫反应和神经系统中的作用。 Cx3cr1的功能: 细胞...
In the present protocol, mice expressing green fluorescent protein (gfp) under the promoter of Cx3cr1 (BALB/c-Cx3cr1 gfp/gfp ) were used to image microglia cells in vivo in the retina. Microglia are resident macrophages of the retina and have been implicated in several retinal diseases 1...
, CX3CR1-deficient mice are used as donors and wild-type mice are used as recipients. In order to detect effects on the "immune cell environment," wild-type donors are used for the transfer into Cx 3 cr1 (-/-) recipients. The resulting chimeric mice can then be used for the ...
Visualization of bone marrow monocyte mobilization using Cx3cr1gfp/+Flt3L-/- reporter mouse by multiphoton intravital microscopydoi:10.1189/jlb.1TA0514-274RMaximilien EvrardShu Zhen ChongSapna DeviLai Guan Ng
8. Maciejewski-Lenoir D, Chen S, Feng L, Maki R, Bacon KB: Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia. J Immunol 1999, 163:1628-1635. 9. Pan Y, Lloyd C, Zhou H, Dolich S, Deeds J, Gonzalo JA, Vath J, ...
你好，我这边（上海交通大学）需要CX3CR1-GFP转基因小鼠，能送给我们几对吗？谢谢
Maciejewski-Lenoir D, Chen S, Feng L, Maki R, Bacon KB: Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia. J Immunol. 1999, 163: 1628-1635. CAS PubMed Google Scholar Pan Y, Lloyd C, Zhou H, Dolich S, Deeds J, Gonz...
is the sole member of the CX3C-chemokine subfamily and binds to its specific receptor CX3CR1.21,22 After proteolytic cleavage, this membrane-bound glycoprotein assumes a soluble form that induces migration and activation of CX3CR1-bearing cells such as T cells, natural 1UPMC University Paris 6...
After 1 hour, cell suspensions were directly analyzed by flow cytometry. Adoptive transfer experiment Bone marrow monocytes were isolated from CX3CR1gfp/+ and CX3CR1gfp/gfp mice 5 days after CP treatment and labeled in PBS with Hoechst 33342 (3 μM) and CMTMR (10 μM), respectively. ...
J: GFP signal (yellow arrow) indicating endogenous CX3CR1 expression (green channel). K: Yellow arrow indicates cell that is CX3CR1+ but pro-SPC−, and white arrows indicate cells that are pro-SPC+ but CX3CR1− (merged channels). L and M: Serial sections from AKR/J mouse lungs...