免疫细胞研究:Cx3cr1-GFP小鼠用于研究单核细胞、巨噬细胞和树突状细胞的分布、功能及其在免疫反应中的作用。 神经系统研究:Cx3cr1-GFP小鼠用于研究微小胶质细胞在神经系统中的分布、功能及其在神经炎症、神经退行性疾病中的作用。 细胞迁移和粘附研究:研究Cx3cr1在细胞迁移和粘附中的角色,揭示其在炎症和组织修复中...
, CX3CR1-deficient mice are used as donors and wild-type mice are used as recipients. In order to detect effects on the "immune cell environment," wild-type donors are used for the transfer into Cx 3 cr1 (-/-) recipients. The resulting chimeric mice can then be used for the ...
你好，我这边（上海交通大学）需要CX3CR1-GFP转基因小鼠，能送给我们几对吗？谢谢
Visualization of bone marrow monocyte mobilization using Cx3cr1gfp/+Flt3L-/- reporter mouse by multiphoton intravital microscopydoi:10.1189/jlb.1TA0514-274RMaximilien EvrardShu Zhen ChongSapna DeviLai Guan Ng
雄性野生型(wt)C57Bl/6,LDLr−/− 和LDLr−/−CX3CR1−/− (=CX3CR1gfp/gfp),(美国马萨诸塞州巴尔港杰克逊实验室)通过聚合酶链反应(PCR)进行基因分型,用于年龄匹配组,并保存在特定的无病原体条件下。动物实验...
J: GFP signal (yellow arrow) indicating endogenous CX3CR1 expression (green channel). K: Yellow arrow indicates cell that is CX3CR1+ but pro-SPC−, and white arrows indicate cells that are pro-SPC+ but CX3CR1− (merged channels). L and M: Serial sections from AKR/J mouse lungs...
Maciejewski-Lenoir D, Chen S, Feng L, Maki R, Bacon KB: Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia. J Immunol. 1999, 163: 1628-1635. CAS PubMed Google Scholar Pan Y, Lloyd C, Zhou H, Dolich S, Deeds J, Gonz...
is the sole member of the CX3C-chemokine subfamily and binds to its specific receptor CX3CR1.21,22 After proteolytic cleavage, this membrane-bound glycoprotein assumes a soluble form that induces migration and activation of CX3CR1-bearing cells such as T cells, natural 1UPMC University Paris 6...
After 1 hour, cell suspensions were directly analyzed by flow cytometry. Adoptive transfer experiment Bone marrow monocytes were isolated from CX3CR1gfp/+ and CX3CR1gfp/gfp mice 5 days after CP treatment and labeled in PBS with Hoechst 33342 (3 μM) and CMTMR (10 μM), respectively. ...
Previous studies have shown that CCL2/CX3CR1 deficient mice on C57BL/6N background (with rd8 mutation) have an early onset (6 weeks) of spontaneous retinal degeneration. In this study, we generated CCL2 −/−CX3CR1 GFP/GFP mice on the C57BL/6J background. Retinal degeneration was ...