Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease in young patients and is characterized by the loss of pancreatic 尾 cells; as a result, the body becomes insulin deficient and hyperglycemic. Administration or injection of exogenous insulin cannot mimic the endogenous ...
Here, we provide an overview of the promising therapeutic avenues for Batten disease, highlighting current FDA-approved clinical trials and prospective future treatments. Key points The FDA approval of the enzyme replacement therapy cerliponase alfa (Brineura) for the treatment of CLN2 Batten disease...
Although PAD patients with CLI receive these treatments, they are sometimes unable to deliver sufficient blood flow to eliminate their symptoms. Thus specific strategies are needed to promote enough blood flow. To establish the effective method, many investigations have been performed using cell-based ...
On April 4, 2024, India's first home-grown gene therapy for cancer treatment launched by President Smt. Draupadi Murmu at the Indian Institute of Technology (IIT) Bombay. This series of treatments is named “CAR-T cell therapy”, which is a cancer immunotherapy treatment. 'NexCAR19 CAR T...
Type I diabetes (T1D) patients rely on cumbersome chronic injections of insulin, making the development of alternate durable treatments a priority. The abi... R Desgraz,C Bonal,PL Herrera - 《Trends Endocrinol Metab》 被引量: 146发表: 2011年 Beta-cell replacement for insulin-dependent diabetes...
The Wisconsin Epidemiologic Study of Diabetic Retinopathy XXIII: the twenty-five-year incidence of macular edema in persons with type 1 diabetes. Ophthalmology. 2009;116:497–503. 16. Jones CD, Greenwood RH, Misra A, Bachmann MO. Incidence and progression of diabetic retinopathy during 17 years ...
A particular reason for this – apart from the general aging of our society – is the evident implication of obesity and type 2 diabetes, two emerging public health challenges, in PDAC etiology [5,6,7]. Life style habits, including alcohol and tobacco abuse, which are well-known to ...
The outcome of care in people with type 1 and type 2 diabetes following switching to treatment with either insulin glargine or insulin detemir in routine g... Background: Two alternative basal analogue insulin treatments are available in the UK: insulin glargine and insulin detemir. The purpose ...
Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus. Nat Rev Endocrinol 2016; 12: 566-92.Tahrani, A. A., Barnett, A. H. & Bailey, C. J. Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus. Nat. Rev. Endocrinol. 12,...
Other indications currently being tested in clinical trials with PSC-based therapies are spinal cord injury, severe heart disease and type 1 diabetes. The next generation of PSC-based clinical trials will probably include a PSC-derived dopaminergic neuron therapy for Parkinson disease, and improvements...