According to well established evidence, modern treatment of newly diagnosed acute promyelocytic leukemia (APL) should consist of all-trans retinoic acid (ATRA) and concomitant anthracycline-based chemotherapy. In fact, a number of large multi-center trials including high numbers of patients with prolong...
Clarkson B, Gee T, Arlin Z, Mertelsmann R, Kempin S, Dinsmore R, O'Reilly R, Andreef M, Berhan E, Higgins C, Little C, Cirrincione C, Ellis S: Current status of treatment of acute leukemia in adults: An overview, in Buechner Th (ed): Therapy of Acute Leukemia. Berlin, ...
Even if all Ph chromosome-positive cells are not eliminated, there is the theoretical possibility that autografting reduces the population of malignant stem cells at risk for further mutation, thereby reducing the risk or slowing progression to CML blast crisis. Thus, the infusion of autologous mar...
Childhood acute lymphocytic leukemia: Progress and problems in treatment Acute lymphocytic leukemia is the most common cancer of childhood. A series of total therapy studies begun in 1962 at St. Jude Children's Research Hospital in Memphis, Tennessee has had a dramatic impact on the survival of ...
In an AML trial from the German Study Alliance Leukemia, combination of sorafenib with standard induction and IDAC consolidation was evaluated in older patients. Treatment in the sorafenib arm did not result in significant improvement in EFS or OS.36 This was also true for subgroup analyses, ...
Initial treatment of CML patients with hydroxyurea is usually a daily dose of 1-4 grams, depending on the white blood count, presence of symptoms, and urgency to lower the white blood count. Leukapheresis is reserved for patients presenting with signs or symptoms of leukostasis. As the white ...
However, the treatment of the elderly ineligible for intensive chemotherapy remains a challenge. Low-dose of subcutaneous cytarabine or hypomethylating agents (HMA) have been studied this group. There are no studies investigating physician practice variation in treating AML in Brazil.Methods: We ...
Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives. Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) with a unique morphological appearance, associated coagulopathy an... Derek,McCulloch,Christina,... - 《...
The results of treatment of 629 previously untreated adults with acute leukemia at Memorial Hospital are reviewed. During the past 14 years, 135 adults (>15 years) with acute lymphoblastic leukemia (ALL) have been treated with one of three successive multidrug-intensive treatment protocols (L2, L1...
: Monoclonal antibody-based therapies for leukemia and lymphoma: Blood 1992; 80: 863–878 Rabinowe SN, Grossbard ML, Nadler LM: Innovative treatment strategies for chronic lymphocytic leukemia: monoclonal antibodies, immunoconjugates, and bone marrow transplantation. In: Chronic Lymphocytic Leukemia: ...