Within the past 15 years, the management of chronic lymphocytic leukemia (CLL) has shifted from palliative efforts to modern combination therapies that aim to induce durable remissions and prolong life. A widened spectrum of regimens and novel tools to predict response allows for the tailoring of ...
In an AML trial from the German Study Alliance Leukemia, combination of sorafenib with standard induction and IDAC consolidation was evaluated in older patients. Treatment in the sorafenib arm did not result in significant improvement in EFS or OS.36 This was also true for subgroup analyses, ...
Clarkson B, Gee T, Arlin Z, Mertelsmann R, Kempin S, Dinsmore R, O'Reilly R, Andreef M, Berhan E, Higgins C, Little C, Cirrincione C, Ellis S: Current status of treatment of acute leukemia in adults: An overview, in Buechner Th (ed): Therapy of Acute Leukemia. Berlin, ...
It can be concluded that the therapy for acute lymphocytic leukemia has indeed been developed in a rational manner. Within the three decades of therapy evolution, evidence has accumulated that for some children with this disease cure is now a realistic goal. Two major areas of concern remain. ...
(PhaseI andII)ofdasatinibornilotinibinthetreatmentofimatinib-resistantor-intolerantPh chromosome-positiveleukemiahavealreadyreportedaremarkablerateofhematologic responsegreaterthan90%forchronic-phasepatients.Thesedrugsminimizetheriskof acquireddrugresistancethatisparticularlyseenwithinthefirst24-36monthsof therapy,and...
(2001) Perspectives on the future of chronic myeloid leukemia treatment. Seminars in ... JM Goldman,R Szydlo,MM Horowitz,... - 《Blood》 被引量: 622发表: 1993年 New insights in biology and current therapeutic options for patients with chronic myelogenous leukemia BACKGROUND AND OBJECTIVE: ...
The results of treatment of 629 previously untreated adults with acute leukemia at Memorial Hospital are reviewed. During the past 14 years, 135 adults (>15 years) with acute lymphoblastic leukemia (ALL) have been treated with one of three successive multidrug-intensive treatment protocols (L2, L1...
Current status of treatment of acute leukemia in adults: An overview of the memorial experience and review of literature The results of treatment of 629 previously untreated adults with acute leukemia at Memorial Hospital are reviewed. During the past 14 years, 135 adults (&g... Bayard D. ...
Patients with chronic lymphocytic leukemia (CLL) will likely see a new standard of care based on outcomes in a phase 3 trial for patients treated with a combination of ibrutinib and rituximab. A combination of ibrutinib and rituximab keeps patients with a common form of leukemia...
Conclusion: advances in current treatment for patients with newly diagnosed multiple myeloma SLonial. (2013) Conclusion: advances in current treatment for patients with newly diagnosed multiple myeloma. Leukemia Supplements 2 , S28-S29 /S Lonial. (2013) Conclusion: advances in current treatment for...