The article discusses the development of molecular treatments for chronic myeloid leukemia (CML), a clonal disease of hematopoietic stem cells characterized by the reciprocal translocation t(9;22)(q34;q11), which forms the Philadelphia (Ph) chromosome. Interferon-α (IFN-α) therapy ...
Clinicians treating patients withgenetic mutationslikely to cause leukemia would like to know as well, because their options range from light-handed monitoring or drugs to invasive procedures including radiation, chemotherapy andstem cell transplants. "Right now, the gold standard for treatment is abon...
Acute promyelocytic leukemia (APL), which was once considered one of the deadliest types of leukemia, has become a curable malignancy since the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) as clinical treatments. ATO, which h
The findings of the research, published in the Nature journalLeukemia, provide new insights into why some patients respond to new cancer drugs and why others are resistant. Understanding these responses at a molecular level can help scientists and clinicians working alongside each other to more effic...
these patients invariably require an involved interdisciplinary team of case managers, clinical pharmacists, infectious disease specialists, and nutritionists. Additionally, many organizations such as the Leukemia and Lymphoma Society offer useful resources at no cost, such as live chats and a helpline. ...
In an AML trial from the German Study Alliance Leukemia, combination of sorafenib with standard induction and IDAC consolidation was evaluated in older patients. Treatment in the sorafenib arm did not result in significant improvement in EFS or OS.36 This was also true for subgroup analyses, ...
are chemotherapy drugs designed to treat cancer. They’re an option if you don’t respond to other medications. They curb your immune system and prevent it from attacking nerve coverings. Novantrone has an FDA "black box" warning because it can lead to heart damage and a type of leukemia...
In an interview, Andrew Kuykendall, MD, discussed fedratinib’s potential as an effective option for patients with myelodysplastic syndrome/myeloproliferative neoplasms and chronic neutrophilic leukemia. Read More Understanding and Treating Mucosal Melanoma ...
Factors Influencing Long-Term Leukemia-Free Survival after Allogeneic Bone Marrow Transplantation for Acute Leukemia Initially, transplants in acute myeloblastic leukemia (ANL) were only carried out in patients who had relapsed after failing to respond to the best availa... FE Zwaan,J Hermans,A Ly...
erythroleukemia a malignancy of the blood characterized by abnormally productive bone marrow and the development of oddly-shaped blood cells. glioma any of the predominant category of brain tumors composed of cancerous glial cells (a type of nerve cell). ...