FDA Grants Breakthrough Therapy Designation to Merck’s Sacituzumab Tirumotecan for Metastatic Nonsquamous Non-Small Cell Lung Cancer Don Tracy, Associate Editor December 4th 2024 Article The breakthrough designation is based on data from the expansion cohort of a Phase I/II study evaluating sac...
Last year, the first immunotherapy of this kind was approved foruse by the FDA. The treatment's approval was undeniably a milestone for this new kind of therapy, but alongside the approval came a striking price tag. Kymriah, for young patients with a type of blood and bone marrow ...
This dual cancer-specific targeting strategy provides an effective approach for treating breast and other human neoplasms with the potential for eradicating both primary tumors and metastatic disease. Additionally, these studies support the potential use of mda-7/IL-24 in the therapy of malignant ...
However, cancer cells can persist following treatment with drugs that are not MDR substrates. Another potential mechanism is survival signaling mediated through growth factors expressed by adjacent cells in the tumor microenvironment or metastatic niche (Guise, 2010). For example, the CXCR4 receptor ...
Liver Cancer Rafael Pharmaceuticals has initiated a multicenter, randomized phase 1b/2 clinical trial of devimistat (CPI-613) in combination with gemcitabine and cisplatin in patients with locally advanced, unresectable or metastatic biliary tract cancer who have had no prior treatment. The trial ai...
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Saghatelyan T, Tananyan A, Janoyan N, et al. Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: A comparative, randomized, double-blind, placebo-controlled clinical trial [published online ahead of print, 2020 Apr 18].Phytomedicine...