Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature 553, 91-95. doi: 10.1038/nature25015Sicinski, Piotr,Bu,etc.Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance[J].2018,553(Jan.4 TN.7686)...
Abundance of PD-L1, the ligand of the anti-cancer immunotherapy target PD-1, is negatively regulated by poly-ubiquitination via the cyclin D–CDK4/cullin 3–SPOP axis and PD-1 blockade treatment in mice improved survival when combined with CDK4/6 inhibit
而在乳腺癌细胞研究中[27]发现Cul3-SPOP连接酶介导了乳腺癌转移抑制因子(breast cancer metastasis suppressor 1,BRMS1)泛素化降解。在敲除了SPOP后发现BRMS1表达的增高并抑制了OPN及uPA的表达水平,因此推测Cul3-SPOP泛素连接酶能促进乳腺癌的发展。以上研究为肿瘤的治疗提供了新的思路。 4.3Cullin3-KEAP1-Nrf2影响...
泛素连接酶Cullin3的研究进展李衍辉1,梁雅灵2,徐勇1*[摘要]泛素-蛋白酶体系统(ubiquitin-protesomesystem,UPS)是蛋白质翻译后修饰的重要调控途径,是生物体内最主要的蛋白质选择性降解方式。Cullin3以支架蛋白的形式通过跟具有BTB结构域的接头蛋白结合共同构成E3泛素连接酶复合体,特异性识别底物并介导底物蛋白的泛素化,...
SPOP is a BTB-domain adaptor of the cullin-3 E3 ligase complexes; it selectively recruits substrates via its N-terminal MATH domain, whereas its BTB domain mediates dimerization and interactions with cullin-3. It has recently been recognized that the high-order oligomerization of SPOP enhances ...
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 2018;553(7686):91-5.Zhang, Jinfang,Bu,etc.Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance[J].2018,553(Jan.4 TN.7686)....
Cullin 3UbiquitinSPOPKeap 1TumorigenesisMouse modelsCullin 3-RING ligases (CRL3) play pivotal roles indoi:10.1016/j.bbcan.2017.11.001Ji Cheng a bJianping Guo bZhiwei Wang b cBrian J. North bKaixiong Tao aXiangpeng Dai bWenyi Wei b
Cullin3immune checkpointimmunotherapyPD-L1SNX6SPOPubiquitinationProgrammed death ligand 1 (PD-L1) is critical for the ability of cancer cells to evade attacks by the host immune system. However, the molecular mechanisms controlling PD-L1 expression have not been fully understood. Here, we demonstrate...