Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature 553, 91-95. doi: 10.1038/nature25015Sicinski, Piotr,Bu,etc.Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance[J].2018,553(Jan.4 TN.7686)...
Abundance of PD-L1, the ligand of the anti-cancer immunotherapy target PD-1, is negatively regulated by poly-ubiquitination via the cyclin D–CDK4/cullin 3–SPOP axis and PD-1 blockade treatment in mice improved survival when combined with CDK4/6 inhibit
而在乳腺癌细胞研究中[27]发现Cul3-SPOP连接酶介导了乳腺癌转移抑制因子(breast cancer metastasis suppressor 1,BRMS1)泛素化降解。在敲除了SPOP后发现BRMS1表达的增高并抑制了OPN及uPA的表达水平,因此推测Cul3-SPOP泛素连接酶能促进乳腺癌的发展。以上研究为肿瘤的治疗提供了新的思路。 4.3Cullin3-KEAP1-Nrf2影响...
To identify specific amino acid residues in KLHL15 that mediate binding to CUL3, we performed multiple sequence alignments of various human BTB-Kelch proteins and the MATH-BTB protein SPOP. This revealed the presence of a conserved, paired helix structure following the BTB domain of KLHL15, ...
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature 553, 91-95. doi: 10.1038/nature25015Sicinski, Piotr,Bu,etc.Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance[J].2018,553(Jan.4 TN.7686)...
Cullin 3 and Its Role in TumorigenesisCullin3 ubiquitin ligaseCancerKeap1SPOPKLHL20LZTR1Cullin 3 (Cul3) family of ubiquitin ligases comprises three components, the RING finger protein RBX1, the Cul3 scaffold, and a Bric-a-brac/Tramtrack/Broad complex (BTB) protein. The BTB protein......
Cullin 3UbiquitinSPOPKeap 1TumorigenesisMouse modelsCullin 3-RING ligases (CRL3) play pivotal roles indoi:10.1016/j.bbcan.2017.11.001Ji Cheng a bJianping Guo bZhiwei Wang b cBrian J. North bKaixiong Tao aXiangpeng Dai bWenyi Wei b
Cullin3immune checkpointimmunotherapyPD-L1SNX6SPOPubiquitinationProgrammed death ligand 1 (PD-L1) is critical for the ability of cancer cells to evade attacks by the host immune system. However, the molecular mechanisms controlling PD-L1 expression have not been fully understood. Here, we demonstrate...