Significant conformational changes were observed among several regions of the Cullin1 and RBX1 proteins after Nedd8 modification, which supports the theory that neddylation enables the unwinding of RBX1 from the Cul1-CTD and embraces a more flexible and open confirmation. In RBX1, region 37-53 ...
属第一医院口腔科主任、口腔教研室主任，学科带头人，预防保健体检中心主任。 长期从事口腔医学专业实践，在颅颌面部重点对疑难重症的综合诊治领域开展了多项 技术创新与探索。对头颈颌面部重症疑难病症的诊治实践积累了丰富的临床经验和娴熟的 诊疗操作技术，尤其擅长口腔颌面部较大组织缺损的修复重建和颌面-颅底及颌...
Cullin-1是人Cullin基因家族成员之一,定位于染色体7q36.1,具有26个外显子。Cullin-1蛋白通过球形的C末端结构域结合环状结构域酶(Rbx1/2),通过N末端重复模指跟一个衔接蛋白(Fbox)结合形成SCF泛素联接酶,SCF在众多底物蛋白适时降解中起重要调控作用,从而确保细胞的正常生长调控[8]。 SCF复合物通过调节细胞周期蛋白Cycl...
1b), the Tcon cell proliferation rate (Supplementary Fig. 1c), and the Treg/CD4+ ratio (Supplementary Fig. 1d), suggesting that the role of Sag in Treg cells at the steady state is, if any, not obvious. Strikingly, deletion of Rbx1 in Treg cells (Supplementary Fig. 2a) was early-...
(Cullin 1, 2, 3, 4A, 4B, 5, 7 or 9), a RING finger protein (RBX1 or RBX2), an adaptor protein (SKP1 for CRL1 and CRL7 or EloC/EloB for CRL2 and CRL5, BTB for CRL3, DDB1 for CRL4s and FBXW8 or SMU1 for CRL7) and a receptor-substrate recognition protein (F-box ...
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The Elongin BC-box protein family includes the von Hippel-Lindau tumor suppressor and suppressor of cytokine signaling proteins, which are substrate recognition subunits of structurally related classes of E3 ubiquitin ligases composed of Elongin C-Elongin B-Cullin 2-Rbx1 (Cul2 ubiquitin ligases) or ...
Dysfunction of E3 ubiquitin ligases contributes to abnormal cell growth and differentiation [6]. As the biggest family of E3 ubiquitin ligases, the Skp1/Cullin/Rbx1/F-box protein (SCF) complexes ubiquitinate a broad range of proteins involved in cell-cycle progression, signal transduction and ...
CUL1 consists of three repeats of a five-helix motif at the N-terminus and a globular domain at the C-terminus. SKP1, the adaptor protein, and RBX1 or RBX2, a RING protein, bind to the N-terminus and the C-terminus of CUL1, respectively. Then, SKP1 binds to an F-box receptor, ...
(Cullin-RING ligase-1)as the founding member of CRLs,is the largest family of E3 ubiquitin ligases,consisting of four components:1)an adaptor protein SKP1,2)a scaffold protein cullin-1(CUL1),3)a substrate-recognizing F-box protein,and 4)a RING protein with two family members,RBX1 or RBX...