《番茄泛素连接酶CUL4-DDB1调控DNA甲基化的分子机理》是依托四川大学，由刘永胜担任项目负责人的面上项目。项目摘要 真核生物表观遗传修饰（组蛋白修饰、DNA甲基化等）具有不可或缺的生理功能。本实验室最近发现番茄紫外损伤DNA结合蛋白DDB1基因的功能缺失突变引起基因组某些位点的DNA甲基化程度降低，而相应基因的转录...
CUL-4/DDB-1 is the major E3 ligase to target CDT-1 for degradation in S phaseKim, YoungjoKipreos, Edward
产品名称 DDB1和CUL4关联因子7(DCAF7)重组蛋白 货号 PA1000-834 价格说明 价格:商品在爱采购的展示标价,具体的成交价格可能因商品参加活动等情况发生变化,也可能随着购买数量不同或所选规格不同而发生变化,如用户与商家线下达成协议,以线下协议的结算价格为准,如用户在爱采购上完成线上购买,则最终以订单结算页...
Using affinity pull down and mass spectrometry, we identified the E3 ubiquitin ligase complex Cullin 4〥DB1￤DR3/WDR6 as a binder to OSR1 kinase in a SPAK/OSR1 S﹎otif phosphorylationヾependent manner. This binding was found to be compromised by S﹎otif phosphorylation following osmotic ...
Recently, multiple WD40-repeat proteins (WDR) were found to interact with DDB1 and serve as the substrate-recognition subunits of the CUL4-DDB1 ubiquitin ligase. As more than 150–300 WDR proteins exist in the human genome, these findings impact a wide array of biological processes through ...
The CUL4-DDB1 ubiquitin ligase regulates cell proliferation, survival, DNA repair, and genomic integrity through targeted ubiquitination of key regulators, yet the substrate receptors that dictate the specificity of this ubiquitination machinery have been largely unknown. Recent work identified a family ...
Abdullah AssiriNature Publishing Group UKScientific ReportsAli, A.; Mistry, B.V.; AAhmed, H.; Abdulla, R.; AAmer, H.; Prince, A.; MAlazami, A.; SAlkuraya, F.; Assiri, A. Deletion of DDB1- and CUL4-associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male ...
Human DNA Ligase I Interacts with and Is Tar- geted for Degradation by the DCAF7 Specificity Factor of the Cul4-DDB1 Ubiquitin Ligase Complex. J Biol Chem. 2016; 291(42):21893-902. Epub 2016/08/31. https://doi.org/10.1074/jbc.M116.746198 PMID: 27573245....
Le Rouzic E, Belaïdouni N, Estrabaud E, Morel M, Rain J, Transy C, Margottin-Goguet F: HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase. Cell Cycle 2007, 6: 182–188....